BMVC

产品编号 T10574Cas号 627810-06-4

别名

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM).

为众多的药物研发团队赋能，

让新药发现更简单！

BMVC

产品编号 T10574Cas号 627810-06-4

BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM).

规格	价格	库存
2 mg	¥ 1,540	5日内发货
5 mg	¥ 2,610	5日内发货
25 mg	¥ 9,160	6-8周
50 mg	¥ 11,900	6-8周
100 mg	¥ 17,500	6-8周

大包装 & 定制

加入购物车

实验操作小课堂

联系我们获取更多批次信息

资源下载

产品操作手册

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	BMVC is a potent G-quadruplex (G4) stabilizer and a selective telomerase inhibitor (IC50: ~0.2 μM) with anticancer activities. BMVC inhibits Taq DNA polymerase (IC50: ~2.5 μM).
靶点活性	Telomerase:~0.2 μM , G-quadruplex:~2.5 μM
体外活性	BMVC (0.5 μM; 0-18 days; H1299 cells) treatment markedly increases the percentage of sub-G1-phase cells after 18 days and long-term treatment leads to ceasing cell growth and eventually cell death through apoptosis. The long-term BMVC treatment induces the senescence program in H1299 cells. The BMVC-induced senescence phenotype is accompanied by progressive telomere shortening and detection of the DNA damage foci, indicating that BMVC caused telomere uncapping after long-term treatments [1].
体内活性	The treatment of BMVC (1 mg/kg; i.p.; every 3 day; BALB/cAnN.Cg-Foxn1nu/CrlNarl mice) delays tumorigenic potential of cancer cells in vivo [1].