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(S)-3-Hydroxy Midostaurin
产品编号 T12791Cas号 945260-14-0
别名 (S)-CGP52421
(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)).
(S)-3-Hydroxy Midostaurin
产品编号 T12791 别名 (S)-CGP52421Cas号 945260-14-0
(S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)).
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 mg | ¥ 28,200 | 10-14周 | |
| 50 mg | ¥ 37,800 | 10-14周 | |
| 100 mg | ¥ 49,500 | 10-14周 |
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生物活性
化学信息
| 产品描述 | (S)-3-Hydroxy Midostaurin is a potent inhibitor of kinases(IC50 of <400 nM for 13 kinases (VEGFR-2, TRK-A, FLT3, et)). |
| 体外活性 | (S)-3-Hydroxy Midostaurin(IC50 range of 200-400 nM) against the ITD and D835Y mutants and low micromolar activity against the wild-type enzyme. The epimeric mixture of metabolites ((R)-3-Hydroxy Midostaurin + (S)-3-Hydroxy Midostaurin) substantially inhibits the proliferation of only the Tel-PDGFRβ with GI50 of 63 nM, KIT D816V (GI50=320 nM), and FLT3-ITD (GI50=650 nM) BaF3 cell lines, while the wild-type cells are relatively insensitive. |
| 别名 | (S)-CGP52421 |
| 分子量 | 586.64 |
| 分子式 | C35H30N4O5 |
| CAS No. | 945260-14-0 |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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