Volazocine is a potent orally active agonist with anesthetic-antagonistic properties. It can be synthesized via two independent pathways: one involves nitration followed by reduction of volazocine, and the other utilizes dissolving metal reduction of cyclazocine methyl ether, followed by oximation and the Semmler-Wolff rearrangement sequence. Several analogs have also been prepared and tested in studies.