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Compstatin

Name: Compstatin
Brand: TargetMol
SKU: TP1304
Price: 513 CNY
Availability: InStock
Rating: 5 (10 reviews)

Synonyms: 坎普他汀

货号 TP1304Cas号 206645-99-0 一键复制产品信息

很棒

Compstatin 是一种由 13 个氨基酸残基组成的环肽，是针对补体系统 C3 的有效抑制剂。Compstatin 具有物种特异性，仅对灵长类的补体系统具有抑制作用，研究显示能与狒狒的 C3 结合，并在狒狒血液中对蛋白水解裂解表现出抗性，其对经典途径和旁路途径的 IC50 值分别为 63 μM 和 12 μM。

Compstatin

一键复制产品信息

很棒

货号 TP1304Cas号 206645-99-0

别名 坎普他汀

为众多的药物研发团队赋能，

让新药发现更简单！

规格	价格	库存
500 μg	¥ 513	现货
1 mg	¥ 691	现货
2 mg	¥ 980	现货
5 mg	¥ 1,490	现货
10 mg	¥ 2,230	现货
25 mg	¥ 3,730	现货
50 mg	¥ 5,330	现货
100 mg	¥ 7,290	现货
200 mg	¥ 9,830	现货

库存状态实时更新，以官网显示为准，现货产品可直接加购物车下单

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TargetMol的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

实验操作小课堂

常见问题解答

选择批次:

纯度: >99.99%

颜色: 白色

性状: Solid

资源下载: COA产品操作手册

产品介绍

Compstatin AI Summary

Compstatin demonstrates inhibitory effects on various components of the complement system. It inhibits C3 convertase with an IC50 value of 3400.0 nM and shows inhibition of C3 cleavage, which affects the activity of C3/C5 convertase, with an IC50 value of 12000.0 nM. Additionally, Compstatin inhibits the activation of C3b, as indicated by a logIC50 value of 0.0 compared to compstatin. The compound also inhibits the binding of C3 to the convertase in the alternative pathway (IC50 = 12000.0 nM) and the classical pathway (IC50 = 63000.0 nM), with greater efficacy in the alternative pathway. Furthermore, it has a binding affinity to complement component C3 in human plasma with a Kd of 1300.0 nM, and to complement component C3c with a Kd of 390.0 nM. Compstatin shows high solubility in PBS at pH 7.4, with a solubility of 4500.0 ug/mL determined over a period of 24 to 48 hours. These properties highlight its potential as a modulator of the complement system response..

Note: Summary generated by AI. Data source: ChEMBL

生物活性

产品描述

Compstatin is a cyclic peptide consisting of 13 amino acid residues and is a potent inhibitor of complement system C3. Compstatin is species-specific and has inhibitory effects only on the complement system of primates. Studies have shown that it can bind to baboon C3 and is resistant to proteolytic cleavage in baboon blood. Its IC50 values for the classical pathway and alternative pathway are 63 μM and 12 μM, respectively.

别名

坎普他汀

化学信息

分子量	1550.77
分子式	C₆₆H₉₉N₂₃O₁₇S₂
CAS No.	206645-99-0
Smiles	CC[C@H](C)[C@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)[C@H](Cc2cnc[nH]2)NC(=O)CNC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC1=O)C(C)C)C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
密度	1.56 g/cm3 (Predicted)
Sequence	Ile-Cys-Val-Val-Gln-Asp-Trp-Gly-His-His-Arg-Cys-Thr-NH2 (Disulfide bridge: Cys2-Cys12)
Sequence Short	ICVVQDWGHHRCT (Disulfide bridge: Cys2-Cys12)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

实际储存温度请以COA为准

溶解度信息

DMSO: 115 mg/mL (74.16 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	0.6448 mL	3.2242 mL	6.4484 mL	32.2420 mL
5 mM	0.1290 mL	0.6448 mL	1.2897 mL	6.4484 mL
10 mM	0.0645 mL	0.3224 mL	0.6448 mL	3.2242 mL
20 mM	0.0322 mL	0.1612 mL	0.3224 mL	1.6121 mL
50 mM	0.0129 mL	0.0645 mL	0.1290 mL	0.6448 mL

该溶液配制表仅适用于固体产品。对于液体产品，请根据标明的浓度或密度计算稀释方案。

计算器

摩尔浓度计算器
稀释计算器
配液计算器
分子量计算器

体内实验配液计算器

请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：

比如您的给药剂量是10 mg/kg，每只动物体重20 g，给药体积100 μL，一共给药动物10只，您使用的配方为 10% DMSO + 40% PEG300 + 5% Tween 80 + 45% Saline / PBS / ddH₂O，那么您的工作液浓度为2 mg/mL。

母液配置方法：2 mg 药物溶于 100 μL DMSO （母液浓度为 20 mg/mL ）, 如您需要配置的浓度超过该产品的溶解度，请先与我们联系。