SNT-207858 free base

Name: SNT-207858 free base
Brand: TargetMol
SKU: T12945
Price: 185 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T12945Cas号 1104662-66-9

SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).

SNT-207858 free base

还可以

产品编号 T12945Cas号 1104662-66-9

规格	价格	库存
2 mg	¥ 3,190	5日内发货
5 mg	¥ 3,730	5日内发货
25 mg	¥ 10,600	6-8周
50 mg	¥ 13,800	6-8周
100 mg	¥ 17,500	6-8周
1 mL x 10 mM (in DMSO)	¥ 4,970	5日内发货

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产品介绍

生物活性

产品描述	SNT-207858 free base is a selective, blood brain barrier penetrating, potent and orally active antagonist of melanocortin-4 (MC-4) receptor(IC50 of 22 nM (binding) and 11 nM (function), on the MC-4 receptor).
体外活性	SNT207858 binds to MC-4 receptor with an affinity of 22 nM, and shows a 170-fold selectivity vs. MC-3 and a 40-fold selectivity vs. MC-5.
体内活性	In mice,the tumor induced weight loss significantly reduced by SNT207858 (30 mg/kg; oral administration; once daily; 15 days).

化学信息

分子量	616.62
分子式	C₃₂H₄₃Cl₂N₅O₃
CAS No.	1104662-66-9
密度	1.258 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 125 mg/mL (202.72 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6217 mL	8.1087 mL	16.2174 mL	81.0872 mL
5 mM	0.3243 mL	1.6217 mL	3.2435 mL	16.2174 mL
10 mM	0.1622 mL	0.8109 mL	1.6217 mL	8.1087 mL
20 mM	0.0811 mL	0.4054 mL	0.8109 mL	4.0544 mL
50 mM	0.0324 mL	0.1622 mL	0.3243 mL	1.6217 mL
100 mM	0.0162 mL	0.0811 mL	0.1622 mL	0.8109 mL