AZD5582 dihydrochloride

Name: AZD5582 dihydrochloride
Brand: TargetMol
SKU: T36201
Price: 108 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T36201Cas号 1883545-51-4

别名 AZD 5582 dihydrochloride

Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.

AZD5582 dihydrochloride

还可以

产品编号 T36201 别名 AZD 5582 dihydrochlorideCas号 1883545-51-4

规格	价格	库存	数量
10 mg	¥ 6,820	35日内发货

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生物活性

产品描述	Dimeric Smac mimetic; potent inhibitor of X-linked (XIAP) and cellular (cIAP) inhibitor of apoptosis protein (IC50 values are 15, 15 and 21 nM for XIAP, cIAP1 and cIAP2 respectively). Binds to the BIR3 domain of XIAP to prevent interaction with caspase-9. Causes degradation of cIAP1 and cIAP2 and induces apoptosis in MDA-MB-231 breast cancer cells. Causes tumor regression in MDA-MB-231 xenograft-bearing mice.
靶点活性	CIAP2:21 nM (IC50), XIAP:15 nM (IC50), CIAP1:15 nM (IC50)
别名	AZD 5582 dihydrochloride