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Search Results for " kinase "

Targets Recommended: RIP kinase Aurora Kinase Haspin Kinase LIM Kinase Serine/threonin kinase S6 Kinase Casein Kinase Glucokinase Hexokinase AAK1 (AP2 associated kinase 1) Stemness kinase ROS Kinase Tyrosine Kinases Fer/FerT kinase Tie-2

3084

抑制剂 & 化合物

253

天然产物

12

化合物库

750

重组蛋白

29

同位素标记化合物

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Cat. No.	Product Name
L1600	激酶抑制剂库		2720 compounds
	2720 种激酶抑制剂/调节剂的独特集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L2200	酪氨酸激酶分子库		1016 compounds
	1016 种酪氨酸激酶抑制剂的独特集合，可用于高通量筛选和高内涵筛选；
L1610	FDA 上市激酶抑制剂库		263 compounds
	263种靶向激酶的上市药物集合，用于特定靶向激酶，可用于高通量筛选和高内涵筛选；
L9410	共价抑制剂库		1920 compounds
	1920 种小分子的独特集合，包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子，如氯乙酰基，2-氯丙酰基，丙烯酰基，1-丙-2-炔基，1-丁-2-炔基，酮羰基，二硫键等，可以用于共价抑制剂药物研发；
L1120	AMPK靶向分子库		80 compounds
	80 个靶向AMPK 的分子集合，可用于高通量和高内涵筛选；
L1300	PI3K/Akt/mTOR 化合物库		420 compounds
	420 种与PI3K/Akt/mTOR 相关的生物活性小分子化合物的特有集合，用于PI3K/Akt/mTOR 相关研究以及高通量、高内涵筛选；
L7700	神经再生化合物库		524 compounds
	524 种神经再生相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L2520	糖代谢化合物库		702 compounds
	702 种糖代谢相关的化合物，可用于高通量和高内涵筛选；
L3800	NF-κB 通路分子库		729 compounds
	729 个 NF-κB 信号通路相关的小分子化合物的特有集合，用于高通量、高内涵筛选；
L1400	MAPK 抑制剂库		365 compounds
	365 种与MAPK 信号通路相关的生物活性小分子化合物的特有集合，可用于高通量筛选和高内涵筛选；
L8000	干细胞分化化合物库		1197 compounds
	1197 种干细胞分化信号通路相关的生物活性小分子化合物的特有集合，可用于高通量、高内涵筛选；
L2191	抗乳腺癌化合物库		1939 compounds
	1939 种与乳腺癌相关的化合物，可以用于抗乳腺癌药物研发和药理研究；

化合物库

激酶抑制剂库

Cat.No: L1600

Compounds: 2720

酪氨酸激酶分子库

Cat.No: L2200

Compounds: 1016

FDA 上市激酶抑制剂库

Cat.No: L1610

Compounds: 263

共价抑制剂库

Cat.No: L9410

Compounds: 1920

AMPK靶向分子库

Cat.No: L1120

Compounds: 80

PI3K/Akt/mTOR 化合物库

Cat.No: L1300

Compounds: 420

神经再生化合物库

Cat.No: L7700

Compounds: 524

糖代谢化合物库

Cat.No: L2520

Compounds: 702

NF-κB 通路分子库

Cat.No: L3800

Compounds: 729

MAPK 抑制剂库

Cat.No: L1400

Compounds: 365

干细胞分化化合物库

Cat.No: L8000

Compounds: 1197

抗乳腺癌化合物库

Cat.No: L2191

Compounds: 1939

Cat. No.	Product Name	Target	Signaling Pathways
T6335	Tie2 kinase inhibitor 1 Tie2 kinase inhibitor	Tie-2	Tyrosine Kinase/Adaptors
	Tie2 kinase inhibitor 1 (Tie2 kinase inhibitor) 是Tie2激酶选择性抑制剂9IC50:250 nM)，具有抗癌作用。
T5524	Aurora kinase inhibitor-3 Aurora Kinase Inhibitor III	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Aurora kinase inhibitor-3 (Aurora Kinase Inhibitor III) 是一种有效的，选择性 Aurora A 激酶抑制剂，IC50为 42 nM。
T4191	Multi-kinase inhibitor 1 Multi-kinase inhibitor I	Others; Bcr-Abl; PDGFR; c-Kit	Angiogenesis; Cytoskeletal Signaling; Others; Tyrosine Kinase/Adaptors
	Multi-kinase inhibitor 1 (Multi-kinase inhibitor I) 是多激酶抑制剂。它有用于导致与酪氨酸激酶活性异常或失控有关的疾病或失调的潜力，特别是与c-Kit，PDGF-R，Bcr-abl 活性相关的疾病。
T9040	Aurora kinase inhibitor-2 IUN-70219,Aurora Kinase Inhibitor II	Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic
	Aurora kinase inhibitor-2 (IUN-70219) 是一种可渗透细胞的苯胺喹唑啉，可抑制极光激酶的活性，对Aurora A 和Aurora B 的IC50分别为 390 nM 和 240 nM。
T10276L	AKT Kinase Inhibitor HCl AKT Kinase Inhibitor HCl(842148-40-7 Free base)	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT Kinase Inhibitor HCl 是一种 Akt 抑制剂，具有抗肿瘤活性。
T11184	EML4-ALK kinase inhibitor 1 EML4 ALK kinase inhibitor 1,EML4-ALK kinase inhibitor 1	ALK	Angiogenesis; Tyrosine Kinase/Adaptors
	EML4-ALK kinase inhibitor 1 (EML4 ALK kinase inhibitor 1) 是有效的、具有口服活性的类棘皮细胞微管相关蛋白4-间变性淋巴瘤激酶 (EML4-ALK) 的抑制剂，其 IC50 值为 1 nM。
T60108	PDGFR Tyrosine Kinase Inhibitor III PDGF Receptor Tyrosine Kinase Inhibitor III	PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	PDGFR Tyrosine Kinase Inhibitor III (PDGF Receptor Tyrosine Kinase Inhibitor III) (PDGF Receptor Tyrosine Kinase Inhibitor III)是一种多激酶抑制剂，可抑制 PDGFR、EGFR、FGFR、PKA 和 PKC 等。PDGFR Tyrosine Kinase Inhibitor III 可用于肌萎缩侧索硬化症的研究。
T4692	Protein kinase inhibitors 1 hydrochlorid Protein kinase inhibitors 1 hydrochlorid (1365986-44-2(free base))	Others	Others
	Protein kinase inhibitors 1 hydrochlorid (Protein kinase inhibitors 1 hydrochlorid (1365986-44-2(free base))) 是一种新型 HIPK2 抑制剂，IC50 为 74 nM，Kd 为 9.5 nM。
T16987	TAO Kinase inhibitor 1	Others; MAPK	MAPK; Others
	TAO Kinase inhibitor 1 是一种ATP 竞争性的thousand-and-one amino acid kinases (TAOK)选择性抑制剂，对于 TAOK1 和 TAOK2 的IC50s 分别为 11 nM 和 15 nM。它能够延迟有丝分裂以及诱导有丝分裂细胞死亡。
TP1053L	Protein Kinase C 19-31 acetate Protein Kinase C 19-31 acetate(121545-65-1 free base),PKC (19-31) acetate	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Protein Kinase C 19-31 acetate(121545-65-1 free base) 是一种蛋白激酶 C (PKC) 的肽抑制剂，源自 PKCa 的假底物调节结构域（残基 19-31），在 25 位用丝氨酸取代野生型丙氨酸作为蛋白激酶 C 底物肽，用于测试蛋白激酶 C 活性。
T12721	Rho-Kinase-IN-1	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Rho-Kinase-IN-1 是一种 ROCK 抑制剂，对 ROCK1 和 ROCK2 的 Kis 分别为 30.5 nM 和 3.9 nM。 Rho-Kinase-IN-1 可用于细胞过度增殖、重塑、水肿和炎症疾病的研究。
T8864	Thymidylate Kinase Inhibitor, YMU1	Others	Others
	YMU1 是一种选择性抑制剂，特异性作用于人胸苷酸激酶 (IC50: 610 nM) 。
T9564	IRE1α kinase-IN-1	IRE1	Cell Cycle/Checkpoint
	IRE1α kinase-IN-1 是IRE1α 的选择性抑制剂(IC50为 77 nM)，对 IRE1α 的选择性高于 IRE1β 亚型 100 倍。它抑制内质网诱导的 IRE1α 寡聚和自磷酸化，并抑制 IRE1α RNase 活性 (IC50=80 nM)。
T12728	RIP2 Kinase Inhibitor 3	Others; RIP kinase	Apoptosis; NF-κB; Others
	RIP2 Kinase Inhibitor 3 是一种有效的选择性受体相互作用蛋白2 激酶抑制剂，IC50 为 1 nM。
T64376	Casein kinase 1δ-IN-9	NADPH	Metabolism
	Casein kinase 1δ-IN-9是一种醌还原酶2(Quinone reductase 2)抑制剂，IC50为0.6μM。
T10687	Casein Kinase II Inhibitor IV	Casein Kinase	Metabolism; Stem Cells
	Casein Kinase II Inhibitor IV 是一种小分子诱导剂，可诱导表皮角质形成细胞分化。
T10276	AKT Kinase Inhibitor	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT Kinase Inhibitor 是一种具有抗肿瘤活性的 Akt 抑制剂，以剂量依赖的方式选择性抑制细胞增殖。
T64350	Casein kinase 1δ-IN-3	Casein Kinase	Metabolism; Stem Cells
	Casein kinase 1δ-IN-3 (Casein kinase 1δ-IN-3) (Compound 23a) 是一种酪蛋白激酶 1δ (CK1d) 抑制剂，pIC50 为 6.5376。
T77500	Casein kinase 1δ-IN-6	Casein Kinase	Metabolism; Stem Cells
	Casein kinase 1δ-IN-6 是一种有效且具有选择性的蛋白激酶 CK-1δ 抑制剂，其 IC50 为 23 nM。Casein kinase 1δ-IN-6 在体外和体内实验中均显示出神经保护和抗炎活性。Casein kinase 1δ-IN-6 可用于研究神经退行性疾病。
TP1051L	Protein Kinase C Peptide Substrate acetate Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)	Others	Others
	Protein Kinase C Peptide Substrate acetate(120253-69-2 free base) 以依赖于第二信使和特定衔接蛋白的方式靶向特定细胞间隔物，以响应激活 g 蛋白偶联受体、酪氨酸激酶受体或酪氨酸激酶偶联受体的细胞外信号。
T5466	Tyrosine kinase-IN-1	VEGFR; FGFR; FLT; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tyrosine kinase-IN-1是一种多靶点酪氨酸激酶抑制剂，能够抑制KDR (IC50:4 nM)，Flt-1 (IC50:20 nM)，FGFR1 (IC50:4 nM) 和 PDGFRα (IC50:2 nM)。
TP1271L	Calmodulin-Dependent Protein Kinase II 290-309 acetate Calmodulin-Dependent Protein Kinase II 290-309 acetate (115044-69-4 Free base)	CaMK	Neuroscience
	Calmodulin-Dependent Protein Kinase II 290-309 acetate 是 Ca2+/calmodulin-dependent protein kinase II 的有效拮抗剂（IC50 = 52 nM）。
T9940	Protein kinase G inhibitor-2	Others	Others
	Protein kinase G inhibitor-2 具有抗菌、抗病毒和抗肿瘤活性。
T9779	Protein kinase inhibitor 6	Others	Others
	Protein kinase inhibitor 6 是一种蛋白激酶抑制剂。
T6409	ALK kinase inhibitor-1 SAR348830	Others	Others
	SAR348830 是间变性淋巴瘤激酶ALK 抑制剂。
T67755	Protein kinase G inhibitor-1	PKA	Tyrosine Kinase/Adaptors
	Protein kinase G inhibitor-1是有效的蛋白激酶G 抑制剂，IC50= 0.9 uM。
T9175	Casein Kinase inhibitor A51	Apoptosis; Casein Kinase	Apoptosis; Metabolism; Stem Cells
	Casein Kinase inhibitor A51 是一种具有口服活性的酪蛋白激酶 1α (CK1α) 抑制剂，具有抗癌活性，可诱导白血病细胞凋亡 (apoptosis)，可用于研究颈部癌、急性髓系白血病、乳腺癌和前列腺癌。
T9631	IRAK-4 protein kinase inhibitor 2	IRAK	Immunology/Inflammation; NF-κB
	IRAK-4 protein kinase inhibitor 2 是有效的白介素 1 受体相关激酶 4 抑制剂，IC50为 4 μM。它在与炎症和免疫相关的疾病领域有研究价值。
T77501	TAO Kinase inhibitor 2	Serine/threonin kinase	Cell Cycle/Checkpoint; Metabolism
	TAO Kinase inhibitor 2 是 TAO 激酶抑制剂，IC50为50-500 nM。TAO Kinase inhibitor 2 对 KIAA1361 和 JIK 具有抑制作用，IC50s 为 50-500 nM。
TP1216	CaM kinase II inhibitor TFA salt Autocamtide-2-related inhibitory peptide (TFA)	CaMK	Neuroscience
	CaM kinase II inhibitor TFA salt (Autocamtide-2-related inhibitory peptide(TFA)) 是一种高度特异性和有效的 CaMKII 抑制剂，IC50 为 40 nM。
T4026	SU5408 VEGFR2 Kinase Inhibitor I	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SU5408 (VEGFR2 Kinase Inhibitor I) 是一种可渗透细胞的VEGFR2激酶抑制剂，其IC50=70 nM。
T9229	Pim-1/2 kinase inhibitor 1	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	Pim-1/2 kinase inhibitor 1 是一种具有口服活性的 Pim-1/2 激酶抑制剂。Pim-1/2 kinase inhibitor 1 能阻断 Pim 激酶磷酸化肽的能力，并且抑制4E-BP1和p27Kip1的Pim 蛋白激酶定向磷酸化。Pim-1/2 kinase inhibitor 1 可用于癌症，尤其是前列腺癌的研究。
T77648	Casein kinase 1δ-IN-14 WAY-637081	Others	Others
	Casein kinase 1δ-IN-14（WAY-637081）可用于研究动脉粥样硬化相关心血管疾病。
T60295	Casein kinase 1δ-IN-1 WAY-643895	Casein Kinase	Metabolism; Stem Cells
	Casein kinase 1δ-IN-1 (WAY-643895) 是一种酪蛋白激酶 1δ (CK1δ) 的抑制剂，对CK1δ有抑制作用。Casein kinase 1δ-IN-1 可用于如阿尔茨海默病类的神经退行性疾病的研究。
T77746	Tyrosine kinase-IN-7	EGFR; Antiviral	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Tyrosine kinase-IN-7 是一种有效的酪氨酸激酶 EGFR 抑制剂，抑制 EGFR(WT) 和 EGFR(T790M) ，在多种癌细胞系中显示出抗癌和抗肿瘤活性。Tyrosine kinase-IN-7 具有潜在的抗炎和抗病毒活性。
T9311	mTOR kinase Inhibitor 1	Others	Others
	4-[(E)-{[4,6-Di(4-morpholinyl)-1,3,5-triazin-2-yl]hydrazono}methy l]-2,6-dimethoxyphenol 可用于化学和生命科学领域的研究。
T9315	mTOR kinase Inhibitor 2	Others	Others
	2H-Imidazo[4,5-b]pyrazin-2-one, 1,3-dihydro-6-[6-(1-hydroxy-1-methylethyl)-3-pyridinyl]-1-[(tetrahydro-2H-pyran-4-yl)methyl]- 是有效的mTOR 抑制剂，对于mTOR 和PI3Kα的IC50分别为0.176 μM 和 >30 μM。
T50072	FLT3 kinase inhibitor 2HCl	Others	Others
	3-amino-1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]propan-1-one dihydrochloride 用于多种化合物的合成。
T39482	Casein Kinase inhibitor A86 Casein Kinase inhibitor A86	Others	Others
	Casein Kinase inhibitor A86 is a highly effective and orally bioavailable inhibitor of casein kinase 1α (CK1α). Additionally, it displays inhibitory actions towards CDK7 (TFIIH) and CDK9 (P-TEFb). Furthermore, Casein Kinase inhibitor A86 demonstrates the ability to induce apoptosis in leukemia cells, portraying substantial anti-leukemic effects.
T77708	Casein kinase 1δ-IN-7	Casein Kinase	Metabolism; Stem Cells
	Casein kinase 1δ-IN-7 是一种 Casein kinase 1δ 抑制剂，可用于阿尔茨海默氏病等神经退行性疾病的研究。
T77709	Casein kinase 1δ-IN-8	Casein Kinase	Metabolism; Stem Cells
	Casein kinase 1δ-IN-8 是一种酪蛋白激酶 1δ 的抑制剂，可用于治疗如阿尔茨海默病类型的神经退行性疾病。
T83627	Pim-1 kinase inhibitor 8	Pim; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling
	Pim-1 kinase inhibitor 8 是一种高效的 Pim-1 kinase 抑制剂，具有抗癌活性，可有效抑制细胞迁移。Pim-1 kinase inhibitor 8 对 MCF-7 和 HepG2 细胞有细胞毒性，是研究乳腺癌的候选化合物。
T38841	IRE1α kinase-IN-2 IRE1α kinase-IN-2	Others	Others
	IRE1α kinase-IN-2 is a highly potent inhibitor of IRE1α kinase, demonstrating an EC50 of 0.82 μM. It effectively impedes IRE1α kinase autophosphorylation with an IC50 of 3.12 μM. Additionally, IRE1α kinase-IN-2 effectively inhibits the splicing of XBP1 mRNA in wild-type cell lines.
T40336	IRE1α kinase-IN-6 IRE1α kinase-IN-6	Others	Others
	IRE1α kinase-IN-6 is a potent IRE1α inhibitor with an IC 50 value of 4.4 nM.
T60109	Protein kinase inhibitor H-7 5-(2-methylpiperazine-1-sulfonyl)isoquinoline,蛋白激酶抑制剂H-7,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) 是有效的蛋白激酶 C (PKC) 和环核苷酸依赖性蛋白激酶抑制剂，抑制 PKC 的 Ki 值为 6 μM。
T67944	p38 MAP Kinase Inhibitor Ⅵ	p38 MAPK	MAPK
	p38 MAP Kinase Inhibitor Ⅵ是一种有效的p38 MAP Kinase 抑制剂，具有抗炎活性。
T35525	PI3-Kinase α Inhibitor 2 PI3-Kinase α Inhibitor 2	Others	Others
	Phosphatidylinositol 3-kinase (PI3K) catalyzes the phosphorylation of the 3' hydroxyl position of PIs to produce the second messengers PtdIns-(3,4)-P2 and PtdIns-(3,4,5)-P3. PI3Kα, β, and δ are class 1A enzymes composed of p110 and p85 subunits, whereas PI3Kγ is a class 1B PI3K composed of a p110 catalytic subunit and a p101 or p84 regulatory subunit. PI3Kα inhibitor 2 is a selective inhibitor of PI3Kα with IC50 values of 2, 16, 660, and 220 nM for the α, β, γ, and 2Cβ isoforms, respectively. It...
T22831	Protein kinase inhibitor H-7 dihydrochloride H-7 dihydrochloride	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Protein kinase inhibitor H-7 dihydrochloride(H-7 dihydrochloride0) 是一种有效的蛋白激酶 C（PKC）抑制剂。Protein kinase inhibitor H-7 dihydrochloride（100 μM）显著抑制 TPA (皮肤肿瘤启动子，12-O-tetradecanoylphorbol-13-acetate) 和磷脂酶 C 促使的 ODC (鸟氨酸脱羧酶)，抑制 PMA 诱导的混杂细胞溶解活性。
T14692	BMX-IN-1 BMX kinase inhibitor	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	BMX-IN-1 (BMX kinase inhibitor) 是 X 染色体上的骨髓酪氨酸激酶 (BMX, IC50 = 8 nM) 和相关的布鲁顿酪氨酸激酶 (BTK, IC50 = 10.4 nM) 的特异性抑制剂，但 BMX-IN-1 对 Blk、JAK3、EGFR、Itk 或 Tec 活性的效力要低 47-656 倍以上。
T82174	hRIO2 kinase ligand-1	Others	Others
	hRIO2 kinase ligand-1 是一种有效的 hRIO2 激酶的配体（Kd：520 nM）。

化合物

Tie2 kinase inhibitor 1

Cat.No: T6335

Synonym: Tie2 kinase inhibitor

Target: Tie-2

Aurora kinase inhibitor-3

Cat.No: T5524

Synonym: Aurora Kinase Inhibitor III

Target: Aurora Kinase

Multi-kinase inhibitor 1

Cat.No: T4191

Synonym: Multi-kinase inhibitor I

Target: Others, Bcr-Abl, PDGFR, c-Kit

Aurora kinase inhibitor-2

Cat.No: T9040

Synonym: IUN-70219,Aurora Kinase Inhibitor II

Target: Aurora Kinase

AKT Kinase Inhibitor HCl

Cat.No: T10276L

Synonym: AKT Kinase Inhibitor HCl(842148-40-7 Free base)

Target: Akt

EML4-ALK kinase inhibitor 1

Cat.No: T11184

Synonym: EML4 ALK kinase inhibitor 1,EML4-ALK kinase inhibitor 1

Target: ALK

PDGFR Tyrosine Kinase Inhibitor III

Cat.No: T60108

Synonym: PDGF Receptor Tyrosine Kinase Inhibitor III

Target: PDGFR

Protein kinase inhibitors 1 hydrochlorid

Cat.No: T4692

Synonym: Protein kinase inhibitors 1 hydrochlorid (1365986-44-2(free base))

Target: Others

TAO Kinase inhibitor 1

Cat.No: T16987

Target: Others, MAPK

Protein Kinase C 19-31 acetate

Cat.No: TP1053L

Synonym: Protein Kinase C 19-31 acetate(121545-65-1 free base),PKC (19-31) acetate

Target: PKC

Rho-Kinase-IN-1

Cat.No: T12721

Target: ROCK

Thymidylate Kinase Inhibitor, YMU1

Cat.No: T8864

Target: Others

IRE1α kinase-IN-1

Cat.No: T9564

Target: IRE1

RIP2 Kinase Inhibitor 3

Cat.No: T12728

Target: Others, RIP kinase

Casein kinase 1δ-IN-9

Cat.No: T64376

Target: NADPH

Casein Kinase II Inhibitor IV

Cat.No: T10687

Target: Casein Kinase

AKT Kinase Inhibitor

Cat.No: T10276

Target: Akt

Casein kinase 1δ-IN-3

Cat.No: T64350

Target: Casein Kinase

Casein kinase 1δ-IN-6

Cat.No: T77500

Target: Casein Kinase

Protein Kinase C Peptide Substrate acetate

Cat.No: TP1051L

Synonym: Protein Kinase C Peptide Substrate acetate(120253-69-2 free base)

Target: Others

Tyrosine kinase-IN-1

Cat.No: T5466

Target: VEGFR, FGFR, FLT, PDGFR

Calmodulin-Dependent Protein Kinase II 290-309 acetate

Cat.No: TP1271L

Synonym: Calmodulin-Dependent Protein Kinase II 290-309 acetate (115044-69-4 Free base)

Target: CaMK

Protein kinase G inhibitor-2

Cat.No: T9940

Target: Others

Protein kinase inhibitor 6

Cat.No: T9779

Target: Others

ALK kinase inhibitor-1

Cat.No: T6409

Synonym: SAR348830

Target: Others

Protein kinase G inhibitor-1

Cat.No: T67755

Target: PKA

Casein Kinase inhibitor A51

Cat.No: T9175

Target: Apoptosis, Casein Kinase

IRAK-4 protein kinase inhibitor 2

Cat.No: T9631

Target: IRAK

TAO Kinase inhibitor 2

Cat.No: T77501

Target: Serine/threonin kinase

CaM kinase II inhibitor TFA salt

Cat.No: TP1216

Synonym: Autocamtide-2-related inhibitory peptide (TFA)

Target: CaMK

Cat.No: T4026

Synonym: VEGFR2 Kinase Inhibitor I

Target: VEGFR

Pim-1/2 kinase inhibitor 1

Cat.No: T9229

Target: Pim

Casein kinase 1δ-IN-14

Cat.No: T77648

Synonym: WAY-637081

Target: Others

Casein kinase 1δ-IN-1

Cat.No: T60295

Synonym: WAY-643895

Target: Casein Kinase

Tyrosine kinase-IN-7

Cat.No: T77746

Target: EGFR, Antiviral

mTOR kinase Inhibitor 1

Cat.No: T9311

Target: Others

mTOR kinase Inhibitor 2

Cat.No: T9315

Target: Others

FLT3 kinase inhibitor 2HCl

Cat.No: T50072

Target: Others

Casein Kinase inhibitor A86

Cat.No: T39482

Synonym: Casein Kinase inhibitor A86

Target: Others

Casein kinase 1δ-IN-7

Cat.No: T77708

Target: Casein Kinase

Casein kinase 1δ-IN-8

Cat.No: T77709

Target: Casein Kinase

Pim-1 kinase inhibitor 8

Cat.No: T83627

Target: Pim, PKC

IRE1α kinase-IN-2

Cat.No: T38841

Synonym: IRE1α kinase-IN-2

Target: Others

IRE1α kinase-IN-6

Cat.No: T40336

Synonym: IRE1α kinase-IN-6

Target: Others

Protein kinase inhibitor H-7

Cat.No: T60109

Synonym: 5-(2-methylpiperazine-1-sulfonyl)isoquinoline,蛋白激酶抑制剂H-7,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine

Target: PKC

p38 MAP Kinase Inhibitor Ⅵ

Cat.No: T67944

Target: p38 MAPK

PI3-Kinase α Inhibitor 2

Cat.No: T35525

Synonym: PI3-Kinase α Inhibitor 2

Target: Others

Protein kinase inhibitor H-7 dihydrochloride

Cat.No: T22831

Synonym: H-7 dihydrochloride

Target: PKC

Cat.No: T14692

Synonym: BMX kinase inhibitor

Target: BTK

hRIO2 kinase ligand-1

Cat.No: T82174

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1433	Batatasin III	FAK; Others; Akt	Angiogenesis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Batatasin III 通过抑制上皮间质转化和 FAK-AKT 信号来抑制癌症迁移和侵袭，并具有抗癌活性。 Batatasin III 对整株生长有长期抑制作用，显示出抑制萌发活性。
TQ0183	Narciclasine 水仙环素,Lycoricidinol	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Narciclasine (Lycoricidinol) 是一种植物生长调节剂。它通过调节Rho/Rho 激酶/LIM 激酶/cofilin 信号传导途径，大大增加GTP 酶RhoA 活性以及以RhoA 依赖性方式诱导肌动蛋白应力纤维形成。
T8152	6-Demethoxytangeretin	MAPK; ALK	Angiogenesis; MAPK; Tyrosine Kinase/Adaptors
	6-Demethoxytangeretin 是一种从柑橘分离的黄酮。它能够促进 CRE 介导的转录 (与海马神经元的学习和记忆相关)。它具有抗炎和抗过敏作用，通过间变性淋巴瘤激酶和丝裂原活化蛋白激酶途径抑制人肥大细胞中 IL-6 的产生和基因表达。
T6677	Sophocarpine	ERK; p38 MAPK; NF-κB; TLR; COX; HER; JNK; STAT	Angiogenesis; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Sophocarpine 是一种从传统草药苦参中提取的重要生物碱。苦参具有抗病毒、抗肿瘤和抗炎等多种药理作用。它通过多种机制显著抑制癌细胞的生长，具有抗肿瘤活性。
T2851	Daphnetin 7,8-Dihydroxycoumarin,Daphnetol,瑞香素	EGFR; PKA; PKC; Parasite; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; JAK/STAT signaling; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Daphnetin (7,8-Dihydroxycoumarin) 是从 Genus Daphne 中分离得到的香豆素衍生物，有抗氧化、抗炎、抗疟疾和解热作用，可用于凝血功能障碍、类风湿性关节炎等疾病的相关研究。
T0809	Dicoumarol Dicumarol,双羟香豆素,双香豆素	Dehydrogenase; NADPH; PDK	Metabolism; PI3K/Akt/mTOR signaling
	Dicoumarol (Dicumarol) 是一种 NAD(P)H: 醌氧化还原酶 1 和PDK1的抑制剂，它们的IC50值分别为 0.37 和 19.42 μM。
T5654	Musk ketone	Others	Others
	Musk ketone 可诱导癌细胞生长抑制和凋亡。它增加谷胱甘肽 S-转移酶的活性，因此可能被证明是有用的癌症化学保护剂。
T5796	Plantainoside D Isoplantamajoside,车前草苷D	RAAS; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Endocrinology/Hormones
	Plantainoside D (Isoplantamajoside) 可以抑制 ACE ，IC50=2.17 mM。Plantainoside D 也是IKK-β抑制剂。
T2836	Isorhamnetin 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin	MEK; PI3K; Endogenous Metabolite	MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Isorhamnetin (3-methylquercetin) 是从中草药沙棘中提取的一种类黄酮，可通过抑制MEK1和PI3K 来抑制皮肤癌。
TN1828	Kahweol	Apoptosis; NF-κB; AMPK	Apoptosis; Chromatin/Epigenetic; NF-κB; PI3K/Akt/mTOR signaling
	Kahweol 是小果咖啡的成分之一，可诱导细胞凋亡，具有抗炎、抗血管生成和抗癌活性。它通过激酶的活化抑制的脂肪生成和增加葡萄糖摄取。
T2S2215	Crebanine	Apoptosis; Others; Akt	Apoptosis; Cytoskeletal Signaling; Others; PI3K/Akt/mTOR signaling
	Crebanine 是来自于韦诺萨千金藤的一种生物碱，通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性，还具有抗心律失常的作用。它可诱导人类癌细胞的 G1阻滞和凋亡。
TN1557	Decursinol angelate	ERK; VEGFR; PKC; JNK	Angiogenesis; Chromatin/Epigenetic; Cytoskeletal Signaling; MAPK; Tyrosine Kinase/Adaptors
	Decursinol angelate 是从朝鲜当归根部分离得到的一种天然产物，是 PKC 激酶的激活剂，有细胞毒性，抗肿瘤和抗炎活性。
T4S1796	Heterophyllin B	PI3K	PI3K/Akt/mTOR signaling
	Heterophyllin B 是一种活性环肽，从 Pseudostellaria heterophylla 中分离得到，可用于研究食管癌。
TMS1743	Salvigenin	MAO; Autophagy; ROS Kinase	Autophagy; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Salvigenin 是从鼠尾草中发现的一种多酚类天然产物，具有神经保护、抗肿瘤、免疫调节和细胞毒作用。
TN1299	Desmethylglycitein 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone	PI3K; CDK; PKC	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) 是大豆中苷元的代谢产物，具有抗氧化性和抗癌活性。它是蛋白激酶 C(PKC)α 的直接抑制剂，抑制正常人皮肤成纤维细胞中的太阳紫外线诱导的基质金属蛋白酶1。它在体内直接结合CDK1和CDK2，抑制 CDK1 和 CDK2 活性。
TN1100	Nepodin	transporter; COX; AMPK; Parasite	Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Nepodin 是从Rumex crispus 中分离的一种醌氧化还原酶抑制剂，具有抗糖尿病和抗疟疾的作用。。它通过激活 AMPK 刺激 GLUT4 向质膜的转运。
T3889	Platycodin D	Prostaglandin Receptor; AMPK	Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; PI3K/Akt/mTOR signaling
	Platycodin D 是从桔梗中分离得到的一种皂苷类天然产物，是AMPKα的激活剂，具有抗肥胖活性。它可刺激 TNF-α 合成或抑制 TNF-α mRNA 的降解。
T2746	Sophocarpine monohydrate 槐果碱,Sophocarpine,槐果碱水合物	Apoptosis; Influenza Virus; Akt; PI3K; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling
	Sophocarpine monohydrate 是从传统草药苦参中提取的一种重要生物碱，具有抗肿瘤活性，可用于肝细胞癌，前列腺癌和结肠直肠癌。苦参具有抗病毒，抗肿瘤和抗炎等多种药理作用。
T4672	Brevilin A	Apoptosis; Anti-infection; JAK; STAT; Autophagy	Angiogenesis; Apoptosis; Autophagy; Chromatin/Epigenetic; JAK/STAT signaling; Microbiology/Virology; Stem Cells
	Brevilin A 是从Centipeda minima 中分离的倍半萜内酯，具有抗癌活性。它通过线粒体途径和 PI3K/AKT/mTOR 失活诱导结肠腺癌细胞 CT26 的凋亡和自噬。它是一种选择性JAK-STAT 信号通路抑制剂，通过减弱 JAK 信号和阻塞 STAT3 信号起作用。
T2798	Esculetin 秦皮乙素,二羟基香豆素,Aesculetin,Cichorigenin	Lipoxygenase; Akt; PI3K	Cytoskeletal Signaling; Metabolism; PI3K/Akt/mTOR signaling
	Esculetin (Cichorigenin) 是主要提取自水曲柳的树皮中的活性成分。它能够抑制PI3K/Akt 途径，阻碍血小板衍生生长因子诱导的气道平滑肌细胞表型转换。它具有抗氧化，抗炎和抗肿瘤的活性。
T7190	Actein	Apoptosis; Akt; JNK; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling
	Actein 是从升麻的根茎中分离的一种三萜糖苷，通过促进ROS/JNK 活化和钝化人膀胱癌中的AKT 途径来抑制细胞增殖，诱导自噬和凋亡。
TMS2181	trans-Zeatin (E)-Zeatin,玉米素	ERK; MEK; Endogenous Metabolite	MAPK; Metabolism
	trans-Zeatin ((E)-Zeatin) 是植物细胞分裂素，可抑制紫外线诱导的MEK/ERK 的活化，在细胞生长、分化和分裂中起着重要的作用。
T5771	Hypocrellin A	Antibacterial; PKC; Parasite	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology
	Hypocrellin A 是一种天然的PKC 抑制剂，具有光诱导的抗肿瘤、抗真菌和抗病毒活性，还对 MHC 限制性抗原呈递发挥免疫调节作用。
T4S0498	Glaucocalyxin A 蓝萼甲素,Wangzaozin B,Leukamenin F	Apoptosis; Akt; Caspase; PI3K	Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Glaucocalyxin A (Leukamenin F) 是来自日本黑纹病菌的一种对映型月桂基二萜，具有抗肿瘤作用。它通过调节PI3K/Akt 信号通路抑制 GLI1 的核易位，诱导骨肉瘤凋亡。
TN1405	Arnicolide D 山金车内酯 D,山金车内酯D	Akt; Caspase; PI3K; STAT; mTOR	Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Arnicolide D 是从石胡荽中分离出的一种倍半萜内酯，以浓度和时间依赖性方式抑制鼻咽癌细胞活力。它调节细胞周期，激活 caspase 信号通路并抑制 PI3K/AKT/mTOR 和 STAT3 信号通路。
T6S1302	Carnosol	Nrf2; Endogenous Metabolite; S6 Kinase	Immunology/Inflammation; MAPK; Metabolism; PI3K/Akt/mTOR signaling
	Carnosol 是 Nrf2激活剂，增加 Nrf2 的水平以及能促进血红素氧合酶 1（HMOX1）表达。它是核糖体 S6激酶(RSK2)抑制剂，可用于胃癌相关研究，IC50值约为 5.5 μM。
T1711	Harmine Telepathine,去氢骆驼蓬碱	MAO; 5-HT Receptor; DYRK	Cell Cycle/Checkpoint; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Harmine (Telepathine) 是一种从山茱萸种子中分离出来的生物碱，具有抗癌和抗炎活性。它是双特异性酪氨酸磷酸化调节激酶抑制剂，对5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。
T2869	Emodin Frangula emodin,大黄素	SARS-CoV; Casein Kinase; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Stem Cells
	Emodin (Frangula emodin) 是蒽醌衍生物，有抗SARS-CoV 作用。它阻断 SARS 冠状病毒刺突蛋白和血管紧张素转化酶 2 的相互作用。它抑制酪蛋白激酶 2 ，具有抗炎和抗癌作用。它可改善饮食诱导的肥胖小鼠的代谢紊乱。
T7327	7-Methoxyisoflavone	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	7-Methoxyisoflavone 是单磷酸腺苷活化蛋白激酶 (AMPK) 的激活剂，是异黄酮衍生物。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
TN1134	Euscaphic acid	Apoptosis; LDL; PI3K; DNA/RNA Synthesis; NO Synthase; Prostaglandin Receptor	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; PI3K/Akt/mTOR signaling
	Euscaphic acid 是来源于枣的一种三萜，是DNA 聚合酶抑制剂，可诱导细胞凋亡。它抑制小牛 DNA 聚合酶 α 和大鼠 DNA 聚合酶 β 的IC50值分别为 61 和 108 μM。
T5S1467	Cucurbitacin E	CDK; Autophagy	Autophagy; Cell Cycle/Checkpoint
	Cucurbitacin E 是从黄瓜的攀缘茎中分离得到的一种天然产物。它显着抑制细胞周期蛋白B1/CDC2复合物的活性，具有预防神经变性，具有强效的抗增殖、抗肿瘤、抗炎和镇痛作用行动。
T5S0761	Nitidine chloride	Apoptosis; ERK; FAK; p38 MAPK; NF-κB; Topoisomerase; STAT; Parasite	Angiogenesis; Apoptosis; Cytoskeletal Signaling; DNA Damage/DNA Repair; JAK/STAT signaling; MAPK; Microbiology/Virology; NF-κB; Stem Cells; Tyrosine Kinase/Adaptors
	Nitidine chloride 是从Zanthoxylum nitidum (Roxb) DC 中分离得到的，具有抗疟疾活性。它通过多个靶点通路，起抗癌作用，抑制STAT3、DNA 拓扑异构酶1和2A、ERK 和c-Src/FAK 相关信号通路。它通过MAPK 和NF-kB 途径抑制Lps 诱导的炎性细胞因子的产生。
T3836	Eudesmin	MAPK; S6 Kinase	MAPK; PI3K/Akt/mTOR signaling
	Eudesmin 通过抑制S6K1信号通路来干扰成脂分化，具有抗肿瘤、抗炎和抗菌活性。
T7030	anemarsaponin B 知母皂苷B,知母皂苷 B	p38 MAPK; NF-κB; MEK; COX; NO Synthase	Immunology/Inflammation; MAPK; Neuroscience; NF-κB
	Anemarsaponin B 是一种甾体皂苷，可降低iNOS 和COX-2的蛋白和 mRNA 水平，减少促炎细胞因子的表达和产生。它通过阻断 IκBα 的磷酸化来抑制NF-κB 的 p65 亚基的核转位，还抑制 MAP 激酶激酶 3/6 (MKK3/6) 和混合谱系激酶 3 的磷酸化。
T3904	Gomisin J	Calcium Channel; AMPK	Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Gomisin J 是在五味子中发现的小分子量木脂素，具有血管舒张活性，在非酒精性脂肪性肝病方面有研究潜力。它通过激活 AMPK、LKB1 和 Ca2+/钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白 A 来调节脂肪生成酶和脂肪分解酶以及炎症分子的表达，从而抑制脂质积累。
TN4673	(+)-Nortrachelogenin Wikstromol,荛花酚	Apoptosis; HIV Protease; PI3K; Antifection	Apoptosis; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	(+)-Nortrachelogenin 是一种从 Wikstroemia indica C.A. Meyer （百里香科）中分离出来的木脂素。 (+)-Nortrachelogenin 具有抗白血病活性。
T3881	Vaccarin	Integrin; Akt; PERK; AMPK	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Vaccarin 是从王不留行中提取的一种黄酮糖苷，可显著促进伤口愈合以及伤口部位的内皮和成纤维细胞增殖。它通过激活 AMPK 信号通路改善胰岛素抵抗和脂肪变性。
T4S0800	Demethyleneberberine	P450; NOS; NF-κB; HIF; AMPK	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Demethyleneberberine 是从黄连中提取的一种天然产物，是线粒体靶向抗氧化剂。它也可作为AMPK 激活剂，用于非酒精性脂肪性肝病的研究。它通过抑制NF-κB 通路和调节 Th 细胞的平衡来减轻小鼠结肠炎并抑制炎症反应。
T5497	AMAROGENTIN 苦杏苷,苦龙胆酯苷	Apoptosis; AMPK	Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	Amarogentin 是要从 Swertia 和 Gentiana 根中提取的裂环烯醚萜苷，有抗氧化、抗肿瘤和抗糖尿病活性，具有保肝和免疫调节作用。它通过激活 AMPK 发挥有益的血管代谢作用。它促进细胞凋亡，阻止 G2/M 细胞周期和下调 PI3K/Akt/mTOR 信号通路。
T2811	Harmine hydrochloride telepathine hydrochloride,盐酸哈尔明碱	5-HT Receptor; DYRK; GluR	Cell Cycle/Checkpoint; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors
	Harmine hydrochloride (telepathine hydrochloride) 是一种 DYRK 抑制剂，具有抗癌和抗炎活性。它对5-HT2A 血清素受体具有高亲和力，Ki 值为 397 nM。
T16324	Nimbolide	Apoptosis; NF-κB; CDK	Apoptosis; Cell Cycle/Checkpoint; NF-κB
	Nimbolide 是源自印楝叶和花的一种三萜。它抑制CDK4/CDK6激酶活性。它抑制 NF-κB，Wnt，PI3K-Akt，MAPK 和 JAK-STAT 信号通路。它通过抑制NF-κB 而诱导肿瘤细胞凋亡。
TJS1779	Protosappanin A 原苏木素A,PTA	NADPH-oxidase; IL Receptor; IκB/IKK; TNF; NF-κB; TLR; ROS; COX; HIV Protease; JAK; NO Synthase; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Microbiology/Virology; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells
	Protosappanin A (PTA) 是从苏木中分离得到的免疫抑制成分和主要联苯化合物，通过下调 JAK2和 STAT3的磷酸化，抑制 JAK2/STAT3依赖的炎症通路。
T2933	Wogonin Vogonin,汉黄芩素	Apoptosis; Wnt/beta-catenin; CDK; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Wogonin (Vogonin) 是一种具有细胞渗透性的口服类黄酮，具有抗炎和抗癌特性，能够抑制 CDK8和 Wnt 的活性。
T0167	Vinpocetine 长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate	IκB/IKK; NF-κB; Sodium Channel; PDE	Membrane transporter/Ion channel; Metabolism; NF-κB
	Vinpocetine (RGH-4405) 是一种长春花生物碱衍生物，是阻断 Na+通道的阻断剂。Vinpocetine 抑制IKK 的IC50为 17.17 μM。Vinpocetine 也是PDE 抑制剂，并通过直接靶向IKK 抑制NF-κB 依赖性炎症反应，已被广泛用于研究脑血管疾病。
T1558	Resveratrol 白藜芦醇,trans-Resveratrol,SRT 501	Apoptosis; Mitophagy; IκB/IKK; Lipoxygenase; Sirtuin; COX; NADPH; DNA/RNA Synthesis; Nrf2; Antibacterial; Antibiotic; Autophagy; Antifungal	Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	Resveratrol (SRT 501) 属于多酚类天然产物，是一种植物抗毒素，具有抗氧化和化学预防活性。Resveratrol 的靶点广泛，包括 COX、SIRT、LOC 等。Resveratrol 可以诱导细胞自噬和凋亡。
T6630	Quercetin Dihydrate 槲皮素,Sophoretin	Apoptosis; PI3K	Apoptosis; PI3K/Akt/mTOR signaling
	Quercetin Dihydrate (Sophoretin) 是一种黄酮类天然产物，可激活或抑制许多蛋白质的活性。它可激活 SIRT1，也可抑制PI3K，抑制 PI3K γ、PI3K δ和PI3K β 的IC50值分别为 2.4 μM、3.0 μM 和 5.4 μM。
T5740	25(R,S)-Ruscogenin (25RS)鲁斯可皂苷元,(25RS)-Ruscogenin	Others; HIF	Angiogenesis; Chromatin/Epigenetic; Others
	25(R,S)-Ruscogenin 能够调节 PI3K/Akt/mTOR 信号通路，抑制 MMP-2、MMP-9、uPA、VEGF 和 HIF-1α 的表达，阻碍肝癌转移。它能够抑制 TLR4信号通路，减轻 LPS 诱导的肺内皮细胞凋亡。
T5S0896	Loureirin A 龙血素 A,龙血素A	Akt; PI3K	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	Loureirin A 是一种黄酮类物质，从龙血树中分离得到，能够降低Akt 的磷酸化，具有抗血小板聚集作用。
T4S1335	Daphnoretin Dephnoretin,西瑞香素,Thymelol	Influenza Virus; Caspase; PKC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome
	Daphnoretin (Thymelol) 是从了哥王中提取得到的一种天然产物，具有抗癌和抗病毒活性。它通过在 G2/M 期连续阻断细胞并激活 caspase-3 通路导致 HOS 细胞死亡。
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天然产物

Cat.No: TN1433

Target: FAK, Others, Akt

Cat.No: TQ0183

Synonym: 水仙环素,Lycoricidinol

Target: ROCK

6-Demethoxytangeretin

Cat.No: T8152

Target: MAPK, ALK

Cat.No: T6677

Target: ERK, p38 MAPK, NF-κB, TLR, COX, HER, JNK, STAT

Cat.No: T2851

Synonym: 7,8-Dihydroxycoumarin,Daphnetol,瑞香素

Target: EGFR, PKA, PKC, Parasite, Autophagy

Cat.No: T0809

Synonym: Dicumarol,双羟香豆素,双香豆素

Target: Dehydrogenase, NADPH, PDK

Cat.No: T5654

Target: Others

Plantainoside D

Cat.No: T5796

Synonym: Isoplantamajoside,车前草苷D

Target: RAAS, PKC

Cat.No: T2836

Synonym: 3-methylquercetin,3'-Methylquercetin,Isorhamnetol,异鼠李素,3'-Methoxyquercetin

Target: MEK, PI3K, Endogenous Metabolite

Cat.No: TN1828

Target: Apoptosis, NF-κB, AMPK

Cat.No: T2S2215

Target: Apoptosis, Others, Akt

Decursinol angelate

Cat.No: TN1557

Target: ERK, VEGFR, PKC, JNK

Heterophyllin B

Cat.No: T4S1796

Target: PI3K

Cat.No: TMS1743

Target: MAO, Autophagy, ROS Kinase

Desmethylglycitein

Cat.No: TN1299

Synonym: 4',6,7-三羟基异黄酮,4',6,7-三羟异黄酮,6-羟基大豆苷元,6,7,4'-Trihydroxyisoflavone

Target: PI3K, CDK, PKC

Cat.No: TN1100

Target: transporter, COX, AMPK, Parasite

Cat.No: T3889

Target: Prostaglandin Receptor, AMPK

Sophocarpine monohydrate

Cat.No: T2746

Synonym: 槐果碱,Sophocarpine,槐果碱水合物

Target: Apoptosis, Influenza Virus, Akt, PI3K, AMPK, Autophagy

Cat.No: T4672

Target: Apoptosis, Anti-infection, JAK, STAT, Autophagy

Cat.No: T2798

Synonym: 秦皮乙素,二羟基香豆素,Aesculetin,Cichorigenin

Target: Lipoxygenase, Akt, PI3K

Cat.No: T7190

Target: Apoptosis, Akt, JNK, Autophagy

Cat.No: TMS2181

Synonym: (E)-Zeatin,玉米素

Target: ERK, MEK, Endogenous Metabolite

Cat.No: T5771

Target: Antibacterial, PKC, Parasite

Glaucocalyxin A

Cat.No: T4S0498

Synonym: 蓝萼甲素,Wangzaozin B,Leukamenin F

Target: Apoptosis, Akt, Caspase, PI3K

Cat.No: TN1405

Synonym: 山金车内酯 D,山金车内酯D

Target: Akt, Caspase, PI3K, STAT, mTOR

Cat.No: T6S1302

Target: Nrf2, Endogenous Metabolite, S6 Kinase

Cat.No: T1711

Synonym: Telepathine,去氢骆驼蓬碱

Target: MAO, 5-HT Receptor, DYRK

Cat.No: T2869

Synonym: Frangula emodin,大黄素

Target: SARS-CoV, Casein Kinase, Autophagy

7-Methoxyisoflavone

Cat.No: T7327

Target: AMPK

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

Cat.No: TN1134

Target: Apoptosis, LDL, PI3K, DNA/RNA Synthesis, NO Synthase, Prostaglandin Receptor

Cat.No: T5S1467

Target: CDK, Autophagy

Nitidine chloride

Cat.No: T5S0761

Target: Apoptosis, ERK, FAK, p38 MAPK, NF-κB, Topoisomerase, STAT, Parasite

Cat.No: T3836

Target: MAPK, S6 Kinase

anemarsaponin B

Cat.No: T7030

Synonym: 知母皂苷B,知母皂苷 B

Target: p38 MAPK, NF-κB, MEK, COX, NO Synthase

Cat.No: T3904

Target: Calcium Channel, AMPK

(+)-Nortrachelogenin

Cat.No: TN4673

Synonym: Wikstromol,荛花酚

Target: Apoptosis, HIV Protease, PI3K, Antifection

Cat.No: T3881

Target: Integrin, Akt, PERK, AMPK

Demethyleneberberine

Cat.No: T4S0800

Target: P450, NOS, NF-κB, HIF, AMPK

Cat.No: T5497

Synonym: 苦杏苷,苦龙胆酯苷

Target: Apoptosis, AMPK

Harmine hydrochloride

Cat.No: T2811

Synonym: telepathine hydrochloride,盐酸哈尔明碱

Target: 5-HT Receptor, DYRK, GluR

Cat.No: T16324

Target: Apoptosis, NF-κB, CDK

Protosappanin A

Cat.No: TJS1779

Synonym: 原苏木素A,PTA

Target: NADPH-oxidase, IL Receptor, IκB/IKK, TNF, NF-κB, TLR, ROS, COX, HIV Protease, JAK, NO Synthase, STAT

Cat.No: T2933

Synonym: Vogonin,汉黄芩素

Target: Apoptosis, Wnt/beta-catenin, CDK, Autophagy

Cat.No: T0167

Synonym: 长春西丁,RGH-4405,长春西汀,Ethyl apovincaminate

Target: IκB/IKK, NF-κB, Sodium Channel, PDE

Cat.No: T1558

Synonym: 白藜芦醇,trans-Resveratrol,SRT 501

Target: Apoptosis, Mitophagy, IκB/IKK, Lipoxygenase, Sirtuin, COX, NADPH, DNA/RNA Synthesis, Nrf2, Antibacterial, Antibiotic, Autophagy, Antifungal

Quercetin Dihydrate

Cat.No: T6630

Synonym: 槲皮素,Sophoretin

Target: Apoptosis, PI3K

25(R,S)-Ruscogenin

Cat.No: T5740

Synonym: (25RS)鲁斯可皂苷元,(25RS)-Ruscogenin

Target: Others, HIF

Cat.No: T5S0896

Synonym: 龙血素 A,龙血素A

Target: Akt, PI3K

Cat.No: T4S1335

Synonym: Dephnoretin,西瑞香素,Thymelol

Target: Influenza Virus, Caspase, PKC

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Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00157	Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His) dTMP kinase,tmk,Thymidylate kinase	Bacillus anthracis	E. coli
	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 27.8 kDa and the accession number is C3LJ02.
TMPH-02271	BTK Protein, Human, Recombinant (His) BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine-pro...	Human	Baculovirus Insect Cells
	Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in...
TMPY-04172	Adenylate Kinase 1 Protein, Rat, Recombinant (His) adenylate kinase 1	Rat	E. coli
	Adenylate Kinase 1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.8 kDa and the accession number is A6JU73.
TMPY-04356	GSK3B Protein, Human, Recombinant (His) glycogen synthase kinase 3 beta,glycogen synthase <...	Human	Baculovirus Insect Cells
	GSK3B Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 50.4 kDa and the accession number is P49841-2.
TMPH-00713	Polyphosphate kinase Protein, E. coli, Recombinant (His & Myc) Polyphosphoric acid kinase,ATP-polyphosphate phosph...	E. coli	E. coli
	Polyphosphate kinase Protein, E. coli, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 87.7 kDa and the accession number is P0A7B1.
TMPH-02964	UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO) Cmpk1,UMP-CMP kinase,Nucleoside-diphosphate kin...	Mouse	E. coli
	Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 38.2 kDa and the accession number is Q9DBP5.
TMPY-04470	Adenylate Kinase 1 Protein, Human, Recombinant (His) HTL-S-58j,adenylate kinase 1	Human	E. coli
	Adenylate Kinase 1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 23.5 kDa and the accession number is AAH01116.1.
TMPY-04412	Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST) mitogen-activated protein kinase kinase	Human	Baculovirus Insect Cells
	Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its express...
TMPY-04422	Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His) CK1g2,casein kinase 1, γ2,casein kinase 1,...	Human	Baculovirus Insect Cells
	Casein kinase I gamma 2 isoform (CSNK1G2), a member of the large casein kinase I (CKI) subfamily, protein kinase superfamily. It may affect the development of brain, and associate with vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. The CKI family includes several other isoforms (alpha, beta, gamma, and delta). Dishevelled (Dsh), another positive component of the Wnt pathway, becomes phosphorylated in response to Wnt signals. All the CKI isoforms, with the exce...
TMPH-00603	Cytidylate kinase Protein, E. coli, Recombinant (His & SUMO) Cytidine monophosphate kinase,CMP kinase,y...	E. coli	E. coli
	ATP, dATP, and GTP are equally effective as phosphate donors. CMP and dCMP are the best phosphate acceptors.
TMPY-04432	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant SPHK,SPHK1,sphingosine kinase 1,SPK	Human	Baculovirus Insect Cells
	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.7 kDa and the accession number is Q9NYA1-1.
TMPY-04375	Casein Kinase 1 alpha Protein, Human, Recombinant (GST) CKIa,casein kinase 1, alpha 1,casein kinase	Human	Baculovirus Insect Cells
	Casein kinase I isoform alpha, also known as CKI-alpha, CK1 and CSNK1A1, is a cytoplasm protein which belongs to theprotein kinase superfamily, CK1 Ser/Thr protein kinase family and casein kinase I subfamily. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. High expression of CSNK2A1, or concomitantly high expression of CSNK2A1, are independent prognostic factors of poor survival in NSCLC patients. CSNK2A1 are use...
TMPH-00467	Hydroxylysine kinase Protein, Danio rerio, Recombinant (His & Myc & SUMO) hykk,Hydroxylysine kinase	Danio rerio (Zebrafish)	E. coli
	Hydroxylysine kinase Protein, Danio rerio, Recombinant (His & Myc & SUMO) is expressed in E. coli.
TMPY-04403	NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST) nemo-like kinase,LAK1	Human	Baculovirus Insect Cells
	Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. As a serine/threonine-protein kinase, Nemo-like kinase regulates some transcription factors with key roles in cell fate determination. It is a positive effector of the non-canonical Wnt signaling...
TMPY-00548	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) MET proto-oncogene, receptor tyrosine kinase	Cynomolgus,Rhesus	HEK293 Cells
	HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 103.1 kDa and the accession number is G7MM61.
TMPY-00246	HER3/ERBB3 Protein, Rhesus, Recombinant erb-b2 receptor tyrosine kinase 3	Rhesus	HEK293 Cells
	HER3/ERBB3 Protein, Rhesus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 69.5 kDa and the accession number is XP_001113953.2.
TMPY-04385	ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST) death-associated protein kinase 3,DLK,ZIP,ZIPK	Human	Baculovirus Insect Cells
	Death-associated protein kinase 3, also known as DAP kinase 3, ZIP-kinase, DAPK3 and ZIPK, is a nucleus and cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser/Thr protein kinase family and DAP kinase subfamily. DAPK3 / ZIPK contains oneprotein kinase domain. It is a serine/threonine kinase which acts as a positive regulator of apoptosis. It phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. DAPK3 / ZIPK is a homodimer or forms heterodimers with AT...
TMPY-04750	CSNK2A2 Protein, Human, Recombinant CK2A2,CSNK2A1,casein kinase 2, alpha prime polypept...	Human	Baculovirus Insect Cells
	CSNK2A2 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 41.4 kDa and the accession number is P19784.
TMPY-04572	MKK4 Protein, Mouse, Recombinant (His & GST) MKK4,MEK4,PRKMK4,Sek1,JNKK1,Serk1,mitogen-activated protein ...	Mouse	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 4, also known as MAP kinase kinase 4, MAPKK4, JNK-activating kinase 1, MAPK/ERK kinase 4, SAPK/ERK kinase 1, c-Jun N-terminal kinase kinase 1, JNKK, and MAP2K4, is a protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K4 / JNKK1 is a protein kinase that is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. MAP2K4 / ...
TMPY-00636	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) erb-b2 receptor tyrosine kinase 2,EGFR2	Cynomolgus	HEK293 Cells
	HER2/ERBB2 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.8 kDa and the accession number is G7PUM4.
TMPY-03024	HER3/ERBB3 Protein, Rat, Recombinant (His) erb-b2 receptor tyrosine kinase 3	Rat	HEK293 Cells
	HER3/ERBB3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.9 kDa and the accession number is A6KSF8.
TMPY-02813	ErbB4 Protein, Human, Rhesus, Recombinant (His) erb-b2 receptor tyrosine kinase 4	Human,Rhesus	HEK293 Cells
	ErbB4 Protein, Human, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.1 kDa and the accession number is Q15303-1.
TMPY-02477	HER3/ERBB3 Protein, Rhesus, Recombinant (His) erb-b2 receptor tyrosine kinase 3	Rhesus	HEK293 Cells
	HER3/ERBB3 Protein, Rhesus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.1 kDa and the accession number is XP_005571238.1&XP_001113953.2.
TMPY-04431	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) SPHK,SPHK1,SPK,sphingosine kinase 1	Human	Baculovirus Insect Cells
	Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 70.3 kDa and the accession number is Q9NYA1-1.
TMPY-01944	HER2/ERBB2 Protein, Rat, Recombinant (His) EGFR2,erb-b2 receptor tyrosine kinase 2	Rat	HEK293 Cells
	HER2/ERBB2 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 71.2 kDa and the accession number is AAH61863.1.
TMPY-04544	MEK2 Protein, Human, Recombinant (GST) mitogen-activated protein kinase kinase 2,...	Human	Baculovirus Insect Cells
	Dual specificity mitogen-activated protein kinase kinase 2, also known as MAP kinase kinase 2, MAPKK2, ERK activator kinase 2, MAPK / ERK kinase 2, MEK2 and MAP2K2, is a member of the protein kinase superfamily, STE Ser/Thr protein kinase family and MAP kinase kinase subfamily. MAP2K2 / MEK2 contains one protein kinase domain. MEK1 and MEK2 (also known as MAP2K1 and MAP2K2, respectively) are evolutionarily conserved, dual-specificity kinases that mediate Erk1 and Erk2 activation during adhesion ...
TMPH-03088	Arginine kinase/AK Protein, Penaeus monodon, Recombinant (His & SUMO) Pen m 2,AK,Arginine kinase	Penaeus monodon	E. coli
	N/A. Arginine kinase/AK Protein, Penaeus monodon, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 56.0 kDa and the accession number is C7E3T4.
TMPH-00689	Propionate kinase Protein, E. coli O6:H1, Recombinant (His & Myc) tdcD,Propionate kinase	E. coli	E. coli
	Catalyzes the conversion of propionyl phosphate and ADP to propionate and ATP. Propionate kinase Protein, E. coli O6:H1, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 50.4 kDa and the accession number is P59244.
TMPY-04376	PLK1 Protein, Human, Recombinant (His) PLK,STPK13,polo-like kinase 1	Human	Baculovirus Insect Cells
	PLK1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 70.5 kDa and the accession number is P53350.
TMPY-04751	VRK1 Protein, Human, Recombinant PCH1,vaccinia related kinase 1,PCH1A	Human	Baculovirus Insect Cells
	VRK1 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 45.6 kDa and the accession number is Q99986.
TMPY-03719	HER2/ERBB2 Protein, Canine, Recombinant (His) erb-b2 receptor tyrosine kinase 2,EGFR2	Canine	HEK293 Cells
	HER2/ERBB2 Protein, Canine, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 70.4 kDa and the accession number is A8WED5.
TMPY-04761	Creatine kinase B Protein, Human, Recombinant (His) HEL-S-29,CKBB,HEL-211,creatine kinase, brain,BCK,B-...	Human	Baculovirus Insect Cells
	CKB(Creatine kinase B type) contains 1 phosphagen kinase C-terminal domain and 1 phosphagen kinase N-terminal domain. It belongs to the ATP:guanido phosphotransferase family. CKB consists of a homodimer of two identical brain-type CK-B subunits. CKB is a cytoplasmic enzyme involved in cellular energy homeostasis, with certain fractions of the enzyme being bound to cell membranes, ATPases, and a variety of ATP-requiring enzymes in the cell. There, CKB forms tightly coupled microcompartments ...
TMPH-03503	Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO) ATP-AMP transphosphorylase,AK,Adenylate monophosphate ki...	Shigella flexneri	E. coli
	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 43.6 kDa and the accession number is Q83M40.
TMPY-04548	CDK4 Protein, Human, Recombinant (GST) CMM3,PSK-J3,cyclin-dependent kinase 4	Human	Baculovirus Insect Cells
	CDK4 is a member of the Ser/Thr protein kinase family. It is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of CDK4 is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). CDK4 was shown to be responsible for the phosphorylation of retinoblastoma gene product. CDK4 is the ser...
TMPH-01459	Human herpesvirus 7 (HHV-7) (strain JI) Probable ganciclovir kinase (His & Myc) Probable ganciclovir kinase,U69	HHV-7	E. coli
	Human herpesvirus 7 (HHV-7) (strain JI) Probable ganciclovir kinase (His & Myc) is expressed in E. coli.
TMPJ-00412	VEGFR1/FLT-1 Protein, Human, Recombinant (hFc) Vascular endothelial growth factor receptor 1,Vascular perme...	Human	HEK293 Cells
	Human Vascular endothelial growth factor receptor 1(VEGFR-1, FLT-1) is a member of the the class III subfamily of receptor tyrosine kinases (RTKs) and Tyr protein kinase family and CSF-1/PDGF receptor subfamily. VEGFR-1 is widely expressed in human tissues including normal lung, placenta, liver, kidney, heart and brain tissues. It is specifically expressed in most of the vascular endothelial cellsand peripheral blood monocytes. VEGFR-1 contains seven Ig-like C2-type domains and one protein kinas...
TMPH-00639	Hygromycin-B 4-O-kinase Protein, E. coli, Recombinant (His) Hygromycin B phosphotransferase,hph,Hygromycin-B kinase<...	E. coli	E. coli
	The aminoglycoside phosphotransferases achieve inactivation of their antibiotic substrates by phosphorylation. Only phosphorylates hygromycin and closely related compounds such as demethyl analogs and destomycin.
TMPY-04406	Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST) protein kinase D2,nPKC-D2,PKD2,HSPC187	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is widely expressed. It contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. PRKD2 / PKD2 is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-71 an...
TMPY-01601	AXL Protein, Human, Recombinant (His) UFO,ARK,JTK11,AXL receptor tyrosine kinase,Tyro7	Human	HEK293 Cells
	AXL Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 46.5 kDa and the accession number is AAB20305.1.
TMPY-03066	FLT3 Ligand Protein, Mouse, Recombinant (hFc) Ly72L,Flt3lg,fms related tyrosine kinase 3 ligand,F...	Mouse	HEK293 Cells
	FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 45.4 kDa and the accession number is P49772-1.
TMPY-03215	FLT3 Ligand Protein, Human, Recombinant (His) fms related tyrosine kinase 3 ligand,FLT3L,FLT3LG,F...	Human	Baculovirus Insect Cells
	FLT3 Ligand Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 20.2 kDa and the accession number is P49771-1.
TMPH-01454	Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Probable ganciclovir kinase (His) U69,Probable ganciclovir kinase	HHV-6A	E. coli
	Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Probable ganciclovir kinase (His) is expressed in E. coli.
TMPY-06873	FLT3 Ligand Protein, Human, Recombinant FLT3LG,fms related tyrosine kinase 3 ligand,FLT3L,F...	Human	E. coli
	FLT3 Ligand Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.75 kDa and the accession number is P49771-1.
TMPY-04649	ROR1 Protein, Human, Recombinant (His) dJ537F10.1,NTRKR1,receptor tyrosine kinase-like orp...	Human	HEK293 Cells
	ROR1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.4 kDa and the accession number is Q01973.
TMPY-04480	UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His) CMPK,UMPK,UMK,CK,UMP-CMPK,CMK,cytidine monophosphate (UMP-CM...	Human	Baculovirus Insect Cells
	CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid bi...
TMPY-00930	TIE2 Protein, Human, Recombinant (His & hFc) VMCM1,TIE2,CD202B,TEK tyrosine kinase, endothelial,...	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 108.5 kDa and the accession number is AAA61139.1.
TMPY-01064	TIE2 Protein, Human, Recombinant (His) TIE2,VMCM,CD202B,TEK tyrosine kinase, endothelial,V...	Human	HEK293 Cells
	TIE2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 82 kDa and the accession number is AAA61139.1.
TMPY-02361	VEGFR2/KDR Protein, Human, Recombinant (His) VEGFR2,kinase insert domain receptor,VEGFR,FLK1,Flk...	Human	HEK293 Cells
	VEGFR2/KDR Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 84.6 kDa and the accession number is P35968-1.
TMPY-05394	ROR2 Protein, Human, Recombinant (His) BDB,BDB1,NTRKR2,receptor tyrosine kinase-like orpha...	Human	HEK293 Cells
	ROR2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.8 kDa and the accession number is Q01974.
TMPY-01247	FLT3 Protein, Human, Recombinant (T227M, His) FLK2,FLK-2,CD135,STK1,fms-related tyrosine kinase 3	Human	HEK293 Cells
	FLT3 Protein, Human, Recombinant (T227M, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.7 kDa and the accession number is P36888-1.
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重组蛋白

Thymidylate kinase Protein, Bacillus anthracis, Recombinant (His)

Cat.No: TMPH-00157

Species: Bacillus anthracis

Expression System: E. coli

BTK Protein, Human, Recombinant (His)

Cat.No: TMPH-02271

Species: Human

Expression System: Baculovirus Insect Cells

Adenylate Kinase 1 Protein, Rat, Recombinant (His)

Cat.No: TMPY-04172

Species: Rat

Expression System: E. coli

GSK3B Protein, Human, Recombinant (His)

Cat.No: TMPY-04356

Species: Human

Expression System: Baculovirus Insect Cells

Polyphosphate kinase Protein, E. coli, Recombinant (His & Myc)

Cat.No: TMPH-00713

Species: E. coli

Expression System: E. coli

UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02964

Species: Mouse

Expression System: E. coli

Adenylate Kinase 1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04470

Species: Human

Expression System: E. coli

Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04412

Species: Human

Expression System: Baculovirus Insect Cells

Casein Kinase 1 gamma 2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04422

Species: Human

Expression System: Baculovirus Insect Cells

Cytidylate kinase Protein, E. coli, Recombinant (His & SUMO)

Cat.No: TMPH-00603

Species: E. coli

Expression System: E. coli

Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant

Cat.No: TMPY-04432

Species: Human

Expression System: Baculovirus Insect Cells

Casein Kinase 1 alpha Protein, Human, Recombinant (GST)

Cat.No: TMPY-04375

Species: Human

Expression System: Baculovirus Insect Cells

Hydroxylysine kinase Protein, Danio rerio, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00467

Species: Danio rerio (Zebrafish)

Expression System: E. coli

NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04403

Species: Human

Expression System: Baculovirus Insect Cells

HGFR/c-Met Protein, Cynomolgus, Rhesus, Recombinant (His)

Cat.No: TMPY-00548

Species: Cynomolgus,Rhesus

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Rhesus, Recombinant

Cat.No: TMPY-00246

Species: Rhesus

Expression System: HEK293 Cells

ZIP Kinase/DAPK3 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04385

Species: Human

Expression System: Baculovirus Insect Cells

CSNK2A2 Protein, Human, Recombinant

Cat.No: TMPY-04750

Species: Human

Expression System: Baculovirus Insect Cells

MKK4 Protein, Mouse, Recombinant (His & GST)

Cat.No: TMPY-04572

Species: Mouse

Expression System: Baculovirus Insect Cells

HER2/ERBB2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPY-00636

Species: Cynomolgus

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03024

Species: Rat

Expression System: HEK293 Cells

ErbB4 Protein, Human, Rhesus, Recombinant (His)

Cat.No: TMPY-02813

Species: Human,Rhesus

Expression System: HEK293 Cells

HER3/ERBB3 Protein, Rhesus, Recombinant (His)

Cat.No: TMPY-02477

Species: Rhesus

Expression System: HEK293 Cells

Sphingosine Kinase 1/SPHK1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04431

Species: Human

Expression System: Baculovirus Insect Cells

HER2/ERBB2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-01944

Species: Rat

Expression System: HEK293 Cells

MEK2 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04544

Species: Human

Expression System: Baculovirus Insect Cells

Arginine kinase/AK Protein, Penaeus monodon, Recombinant (His & SUMO)

Cat.No: TMPH-03088

Species: Penaeus monodon

Expression System: E. coli

Propionate kinase Protein, E. coli O6:H1, Recombinant (His & Myc)

Cat.No: TMPH-00689

Species: E. coli

Expression System: E. coli

PLK1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04376

Species: Human

Expression System: Baculovirus Insect Cells

VRK1 Protein, Human, Recombinant

Cat.No: TMPY-04751

Species: Human

Expression System: Baculovirus Insect Cells

HER2/ERBB2 Protein, Canine, Recombinant (His)

Cat.No: TMPY-03719

Species: Canine

Expression System: HEK293 Cells

Creatine kinase B Protein, Human, Recombinant (His)

Cat.No: TMPY-04761

Species: Human

Expression System: Baculovirus Insect Cells

Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03503

Species: Shigella flexneri

Expression System: E. coli

CDK4 Protein, Human, Recombinant (GST)

Cat.No: TMPY-04548

Species: Human

Expression System: Baculovirus Insect Cells

Human herpesvirus 7 (HHV-7) (strain JI) Probable ganciclovir kinase (His & Myc)

Cat.No: TMPH-01459

Species: HHV-7

Expression System: E. coli

VEGFR1/FLT-1 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00412

Species: Human

Expression System: HEK293 Cells

Hygromycin-B 4-O-kinase Protein, E. coli, Recombinant (His)

Cat.No: TMPH-00639

Species: E. coli

Expression System: E. coli

Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04406

Species: Human

Expression System: Baculovirus Insect Cells

AXL Protein, Human, Recombinant (His)

Cat.No: TMPY-01601

Species: Human

Expression System: HEK293 Cells

FLT3 Ligand Protein, Mouse, Recombinant (hFc)

Cat.No: TMPY-03066

Species: Mouse

Expression System: HEK293 Cells

FLT3 Ligand Protein, Human, Recombinant (His)

Cat.No: TMPY-03215

Species: Human

Expression System: Baculovirus Insect Cells

Human herpesvirus 6A (HHV-6 variant A) (strain Uganda-1102) Probable ganciclovir kinase (His)

Cat.No: TMPH-01454

Species: HHV-6A

Expression System: E. coli

FLT3 Ligand Protein, Human, Recombinant

Cat.No: TMPY-06873

Species: Human

Expression System: E. coli

ROR1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04649

Species: Human

Expression System: HEK293 Cells

UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04480

Species: Human

Expression System: Baculovirus Insect Cells

TIE2 Protein, Human, Recombinant (His & hFc)

Cat.No: TMPY-00930

Species: Human

Expression System: HEK293 Cells

TIE2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01064

Species: Human

Expression System: HEK293 Cells

VEGFR2/KDR Protein, Human, Recombinant (His)

Cat.No: TMPY-02361

Species: Human

Expression System: HEK293 Cells

ROR2 Protein, Human, Recombinant (His)

Cat.No: TMPY-05394

Species: Human

Expression System: HEK293 Cells

FLT3 Protein, Human, Recombinant (T227M, His)

Cat.No: TMPY-01247

Species: Human

Expression System: HEK293 Cells

--------- 更多 ---------

Cat. No.	Product Name	Target	Signaling Pathways
T14687	Deucravacitinib BMS-986165	Tyrosine Kinases; JAK; IFNAR; Interleukin	Angiogenesis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells; Tyrosine Kinase/Adaptors
	Deucravacitinib (BMS-986165) 是一种高选择性、口服生物可利用的变构 TYK2 抑制剂，用于治疗自身免疫性疾病。它通过稳定调节 JH2 结构域来阻断受体介导的 Tyk2 激活，可抑制IL-12/23和 I 型IFN 途径。它选择性结合 TYK2 假激酶 (JH2) 结构域，IC50为1.0 nM。
T24046	WNK-IN-11-d3 WNK inhibitor-12,WNKIN12,WNK IN 12,WNK inhibitor 12,WNK-IN-12
	WNK-IN-12 is an effective, selective, and orally active WNK1 kinase inhibitor.
T37044	1,2-Dioleoyl-rac-glycerol-13C3 1,2-Dioleoyl-rac-glycerol-13C3
	1,2-Dioleoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2-dioleoyl-rac-glycerol by GC- or LC-MS. 1,2-dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at the sn-1 and sn-2 positions. It effectively binds the C1 domain to activate conventional protein kinase C forms and serves as a substrate for diacylglycerol kinases and multisubstrate lipid kinase.1,2,3 \|1. Yamaguchi, Y., Shirai, Y., Matsubara, T., et al. Phosphorylation and up-reg...
T10284	ALK-IN-6	Others	Others
	ALK-IN-6 is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK, IC50s: 71 nM, 18.72 nM, and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L).
T13137	TGFβRI-IN-1	TGF-beta/Smad	Stem Cells
	TGFβRI-IN-1 is an oral active and selective inhibitor of TGFβ receptor type I (TGFβRI) kinase(IC50 values of 2 nM and 7.6 μM for TGFβRI and TGFβRII, respectively ).
T10766	Ceritinib D7 LDK378 D7	Others	Others
	Ceritinib D7 (LDK378 D7) is a deuterium-labeled Ceritinib. Ceritinib is an ATP-competitive inhibitor of ALK tyrosine kinase.
TMIH-0610	Zanubrutinib-d5
	Zanubrutinib-d5 是 Zanubrutinib 的氘代化合物。Zanubrutinib 的 CAS 号为 1691249-45-2。Zanubrutinib 是 Bruton tyrosine kinase(Btk) 的选择性抑制剂。
T10962	Dasatinib-d8 BMS-354825 D8	Others	Others
	Dasatinib D8 is deuterium-labeled dasatinib. Dasatinib is a dual Bcr-Abl and Src family tyrosine kinase inhibitor.
T12698	Regorafenib-d3 Regorafenib D3,BAY 73-4506 D3	Others	Others
	Regorafenib D3 is a deuterium labeled Regorafenib. Regorafenib is a multi-targeted receptor inhibitor of tyrosine kinase.
T11384	Gefitinib-d8 ZD1839 D8,Gefitinib D8	Others	Others
	Gefitinib is an EGFR tyrosine kinase inhibitor, with IC50 of 2-37 nM in NR6wtEGFR cells. Gefitinib D8 is a deuterium labeled Gefitinib.
T19312	Erlotinib-d6 hydrochloride CP-358774 D6 hydrochloride,NSC 718781 D6 hydrochloride,Erlotinib D6 hydrochloride,OSI-774 D6 hydrochloride	Others	Others
	Erlotinib Hydrochloride inhibits purified EGFR kinase with an IC50 of 2 nM. Erlotinib D6 hydrochloride a deuterium labeled Erlotinib Hydrochloride.
TMID-0073	Alectinib-d8
	Alectinib-d8 是 Alectinib 的氘代化合物。Alectinib 的 CAS 号为 1256580-46-7。Alectinib 是一种有效的、选择性的、口服具有活力的、ATP 竞争性的ALK抑制剂，其IC50=1.9 nM，Kd=2.4 nM，并且还抑制ALK F1174L和ALK R1275Q，其IC50分别为 1 nM 和 3.5 nM。它还有中枢神经系统渗透能力。
T11639	Imatinib D4 CGP-57148B D4,STI571 D4	Others	Others
	Imatinib D4 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that selectively inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.
T12224	Nilotinib-d6 AMN107 D6	Others	Others
	Nilotinib D6 is a deuterium labeled Nilotinib which is an orally available inhibitor of Bcr-Abl tyrosine kinase ,and with antineoplastic activity.
TMIJ-0154	Lenvatinib-d4
	Lenvatinib-d4 是 Lenvatinib 的氘代化合物。Lenvatinib 的 CAS 号为 417716-92-8。Lenvatinib 是一种口服具有活性的，多靶点酪氨酸激酶抑制剂，能够抑制血管内皮生长因子受体(VEGFR1-3)，成纤维细胞生长因子受体(FGFR1-4)，干细胞因子受体(KIT)，血小板衍生生长因子受体(PDGFR)，转染期间重排(RET)，具有效抗癌的作用。
T11640	Imatinib-d8 CGP-57148B D8,STI571 D8	Others	Others
	Imatinib D8 is a deuterium-labeled Imatinib. Imatinib is an orally bioavailable tyrosine kinases inhibitor that inhibits BCR/ABL, PDGFR, v-Abl, and c-kit kinase activity.
T11229	Erlotinib-d6 OSI-774 D6,NSC 718781 D6,CP-358774 D6	Others	Others
	Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR. Erlotinib D6 is a deuterium labeled Erlotinib .
T35915	Erlotinib-13C6 Erlotinib-13C6
	Erlotinib-13C6 (CP-358774-13C6) is a 13C-labeled Erlotinib. Erlotinib is a directly acting EGFR tyrosine kinase inhibitor, with an IC50 of 2 nM for human EGFR[1]. Erlotinib reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM. Erlotinib is used for the treatment of non-small cell lung cancer[1].Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process[2]...
T13039	Sunitinib-d10 Sunitinib D10,SU 11248 D10	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Sunitinib D10 is a deuterium labeled Sunitinib. Sunitinib is a inhibitor of multi-targeted receptor tyrosine kinase(IC50s of 80 nM and 2 nM for VEGFR2 and PDGFRβ, respectively).
TMIJ-0330	Gilteritinib-d8
	Gilteritinib-d8 是 Gilteritinib 的氘代化合物。Gilteritinib 的 CAS 号为 1254053-43-4。Gilteritinib 是一种 FLT3 抑制剂 (IC50:0.29 nM)，也是一种 AXL 抑制剂 (IC50:0.73 nM)，具有ATP 竞争性。
T12521	Ponatinib-d8 AP24534 D8	Others	Others
	Ponatinib D8 is a deuterium labeled Ponatinib. Ponatinib is an orally active inhibitor of multi-targeted kinase(Abl, PDGFRα, VEGFR2, FGFR1, and Src with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM, respectively).
T19119	3-Hydroxy Midostaurin-D5 CGP52421-D5	Others	Others
	3-Hydroxy Midostaurin-D5 (CGP52421-D5) is a deuterium-labeled 3-Hydroxy Midostaurin which is a metabolite of PKC412. PKC412 effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation (IC50s: 132 nM and 9.8 μM in culture medium and plasma).
TMIJ-0124	Regorafenib-13C-d3
	Regorafenib-13C-d3 是 Regorafenib 的 13C 和氘代化合物。Regorafenib 的 CAS 号为 755037-03-7。Regorafenib 是一种多靶点受体酪氨酸激酶抑制剂，对 RET、C-RAF、VEGFR2、c-Kit、VEGFR1和PDGFRβ 的 IC50为1.5、2.5、4.2、7、13和22 nM。
TMIJ-0267	Upadacitinib-15N-d2
	Upadacitinib-15N-d2 是 Upadacitinib 的 15N 和氘代化合物。Upadacitinib 的 CAS 号为 1310726-60-3。Upadacitinib 是高效选择性的，具有口服活性的JAK1抑制剂，IC50为43 nM，可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。
TMIH-0413	Osimertinib-d6
	Osimertinib-d6 是 Osimertinib 的氘代化合物。Osimertinib 的 CAS 号为 1421373-65-0。Osimtinib 是一种小分子酪氨酸激酶受体抑制剂和抗肿瘤剂，用于治疗选定形式的晚期非小细胞肺癌，其有效抑制 L858R 和 L858R/T790M EGFR，IC50 为 12 和 1 nM。
TMIJ-0147	Gefitinib-d6
	Gefitinib-d6 是 Gefitinib 的氘代化合物。Gefitinib 的 CAS 号为 184475-35-2。Gefitinib 是一种有口服活性的EGFR酪氨酸激酶抑制剂，可诱导细胞自噬，有抗肿瘤活性。它选择性抑制 EGF 刺激的肿瘤细胞生长，并阻断 EGF 刺激的肿瘤细胞中EGFR自磷酸化。
TMID-0003	Ribociclib-d6
	Ribociclib-d6 是 Ribociclib 的氘代化合物。Ribociclib 的 CAS 号为 1211441-98-3。Ribociclib (LEE011) 是一种细胞周期蛋白依赖性激酶 CDK4/6 抑制剂 (IC50=10/39 nM)，具有特异性和口服活性。Ribociclib 具有抗肿瘤活性，可以阻滞细胞周期，抑制肿瘤细胞增殖。
TMIH-0124	Brivanib Alaninate-d4
	Brivanib Alaninate-d4 是 Brivanib Alaninate 的氘代化合物。Brivanib Alaninate 的 CAS 号为 649735-63-7。Brivanib alaninate 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐，IC50值为 25 nM，具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制，对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。
TMIH-0065	Acalabrutinib-d4
	Acalabrutinib-d4 是 Acalabrutinib 的氘代化合物。Acalabrutinib 的 CAS 号为 1420477-60-6。Acalabrutinib 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。

同位素标记化合物

Deucravacitinib

Cat.No: T14687

Synonym: BMS-986165

Target: Tyrosine Kinases, JAK, IFNAR, Interleukin

Cat.No: T24046

Synonym: WNK inhibitor-12,WNKIN12,WNK IN 12,WNK inhibitor 12,WNK-IN-12

1,2-Dioleoyl-rac-glycerol-13C3

Cat.No: T37044

Synonym: 1,2-Dioleoyl-rac-glycerol-13C3

Cat.No: T10284

Target: Others

Cat.No: T13137

Target: TGF-beta/Smad

Cat.No: T10766

Synonym: LDK378 D7

Target: Others

Zanubrutinib-d5

Cat.No: TMIH-0610

Cat.No: T10962

Synonym: BMS-354825 D8

Target: Others

Cat.No: T12698

Synonym: Regorafenib D3,BAY 73-4506 D3

Target: Others

Cat.No: T11384

Synonym: ZD1839 D8,Gefitinib D8

Target: Others

Erlotinib-d6 hydrochloride

Cat.No: T19312

Synonym: CP-358774 D6 hydrochloride,NSC 718781 D6 hydrochloride,Erlotinib D6 hydrochloride,OSI-774 D6 hydrochloride

Target: Others

Cat.No: TMID-0073

Cat.No: T11639

Synonym: CGP-57148B D4,STI571 D4

Target: Others

Cat.No: T12224

Synonym: AMN107 D6

Target: Others

Cat.No: TMIJ-0154

Cat.No: T11640

Synonym: CGP-57148B D8,STI571 D8

Target: Others

Cat.No: T11229

Synonym: OSI-774 D6,NSC 718781 D6,CP-358774 D6

Target: Others

Cat.No: T35915

Synonym: Erlotinib-13C6

Cat.No: T13039

Synonym: Sunitinib D10,SU 11248 D10

Target: VEGFR, PDGFR

Gilteritinib-d8

Cat.No: TMIJ-0330

Cat.No: T12521

Synonym: AP24534 D8

Target: Others

3-Hydroxy Midostaurin-D5

Cat.No: T19119

Synonym: CGP52421-D5

Target: Others

Regorafenib-13C-d3

Cat.No: TMIJ-0124

Upadacitinib-15N-d2

Cat.No: TMIJ-0267

Cat.No: TMIH-0413

Cat.No: TMIJ-0147

Cat.No: TMID-0003

Brivanib Alaninate-d4

Cat.No: TMIH-0124

Acalabrutinib-d4

Cat.No: TMIH-0065

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