TAT-GluN2BCTM is a membrane-permeable peptide that selectively targets active DAPK1 (Death-associated protein kinase 1) for lysosomal degradation, thereby protecting neurons against oxidative stress and NMDAR-mediated excitotoxicity. This compound's role in facilitating neuroprotection makes it a valuable agent for related research studies [1].

该化合物TAT-GluN2BCTM在浓度为200 µM时，随着时间(0.5, 2, 4小时)的增长对NMDA处理的原代神经元培养物中的DAPK1水平呈现下降趋势[1]。

TAT-GluN2BCTM（10 mg/kg; i.v.; 单次）可显著降低大鼠缺血大脑区域的DAPK1水平，且在皮质和纹状体展现显著神经保护效应[1]。同时，TAT-GluN2BCTM能特异性下调活性形式的DAPK1（而非非活性形式）[1]。