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CTX-0294885 hydrochloride is an agarose-supported kinase capture reagent.
CTX-0294885 hydrochloride is an agarose-supported kinase capture reagent.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 800 | 期货 | |
10 mg | ¥ 1,310 | 期货 | |
50 mg | ¥ 3,860 | 期货 | |
100 mg | ¥ 5,560 | 期货 |
产品描述 | CTX-0294885 hydrochloride is an agarose-supported kinase capture reagent. |
体外活性 | CTX-0294885 is a new type of diaminopyrimidine pyrimidine, showing inhibitory activity against a variety of kinases. CTx-0294885 represents a powerful new reagent that can be used to analyze the kinase group signal network and can promote the development of targeted therapeutic strategies. Large-scale affinity purification based on CTx-0294885, followed by LC-MS / MS, can identify 235 protein kinases in MDA-MB-231 cells, including all members of the AKT family, while other AKT families have not been detected Spectral kinase inhibitor. Addition of CTx-0294885 to a mixture of three kinase inhibitors commonly used for kinase enrichment can increase the number of kinase identifications to 261. Using CTx-0294885 in combination with a broad range of specific inhibitors of three other kinases, 799 high-confidence phosphate sites on 183 kinases can be identified, 10% of which are located in the activation loop and include BMP2K, MELK, HIPK2 and Phosphoric acid sites previously not reported on PRKDC. |
别名 | CTX-0294885 hydrochloride |
分子量 | 474.39 |
分子式 | C22H25Cl2N7O |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 370 mg/mL (779.95 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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