TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].

TMX-4113 (compound 21; 1 μM; 4 h) shows a high degradation preference for PDE6D and CK1α in MOLT4 cells [1]. TMX-4113 (0 nM, 40 nM, 200 nM, 1μM; 4h) induces degradation of PDE6D in MOLT4 cells [1]. TMX-4113 (0 nM, 40 nM, 200 nM, 1μM; 4h) degrades over 50% of CK1α at a dose of 40 nM in MM.1S cells [1]. Western Blot Analysis [1] Cell Line: MOLT4 cells Concentration: 1 μM Incubation Time: 4 h Result: Showed a high degradation preference for PDE6D and CK1α. Western Blot Analysis [1] Cell Line: MOLT4 cells Concentration: 0 nM, 40 nM, 200 nM, 1μM Incubation Time: 4 h Result: Induced degradation of PDE6D.