ChoKα Inhibitor-4 is a bioisosteric agent that effectively inhibits human choline kinase α1 (HChoK α1) with an IC50 of 0.66 μM. It demonstrates both inhibitory and antiproliferative effects on cancer cells, induces apoptosis through the mitochondrial pathway, and diminishes the expression of anti-apoptotic proteins [1].

ChoKα抑制剂-4（化合物PL55）在正常人星形胶质细胞NHA上表现出细胞毒性，其半抑制浓度（IC50）为2.5 μM [1]。