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规格 | 价格 | 库存 | 数量 |
---|---|---|---|
500 μg | ¥ 560 | 35日内发货 | |
1 mg | ¥ 962 | 35日内发货 | |
10 mg | ¥ 3,220 | 35日内发货 |
产品描述 | OXSI-2 (Syk Inhibitor) is an inhibitor of Syk with an EC50 of 313 nM and an IC50 of 14 nM. OXSI-2 completely inhibits Adaptor protein LAT Y191 phosphorylation and Syk mediated events in platelets. |
靶点活性 | Syk:14 nM, Syk:313 nM(EC50) |
体外活性 | OXSI-2 (100 nM) does not affect the platelet functional responses induced by Convulxin, and modest shape change is still evident at 1 μM. OXSI-2 (2 μM) completely shape change and blocks GPVI-mediated dense granule release[2]. OXSI-2 (2 μM) inhibits pyroptotic cell death, inflammasome assembly, caspase-1 activation, IL-1β processing and release and mitochondrial ROS generation[3]. |
别名 | OXSI 2, Syk Inhibitor |
分子量 | 353.39 |
分子式 | C18H15N3O3S |
CAS No. | 622387-85-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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