CID755673

CID755673是一种高效选择性 PKD1抑制剂，IC50为182 nM。

产品编号 T2458Cas号 521937-07-5

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CID755673

产品编号 T2458Cas号 521937-07-5

CID755673是一种高效选择性 PKD1抑制剂，IC50为182 nM。

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规格	价格	库存
5 mg	¥ 498	现货
10 mg	¥ 751	现货
25 mg	¥ 1,232	现货
50 mg	¥ 2,125	现货
100 mg	¥ 3,798	现货
1 mL x 10 mM (in DMSO)	¥ 548	现货

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"CID755673"的相关化合物库

产品介绍

生物活性

产品描述	CID755673 is an effective and specific cell-active inhibitor for PKD (IC50: 182 nM); exhibits selective PKD1 inhibition when compared with PLK1, AKT, CAMKIIα, CAK, and PKC isoforms.
靶点活性	PKD:182 nM
体外活性	在大鼠急性胰腺炎模型中,通过对PKD/ PKD1的抑制作用,CID755673可使坏死和胰腺炎的严重程度得到显著改善.
体内活性	在HeLa细胞中,CID755673对PMA诱导的HDAC5核输出有显著阻断作用,且对PKD介导的蛋白质转运也有阻断作用。CID755673可直接抑制LNCaP前列腺癌细胞中PKD1的活性。CID755673有有效阻断前列腺癌细胞的迁移和侵入,并抑制肿瘤细胞增殖和细胞周期分布。
激酶实验	In Vitro Radiometric PKD Kinase Assay: The radiometric kinase assay is carried out by coincubating 0.5 μCi of [γ-32P]ATP, 20 μM ATP, 50 ng of purified recombinant human PKD (PKD1, PKD2, and PKD3) or CAMKIIα proteins, and 2.5 μg of Syntide-2 in 50 μl of kinase buffer that contains 50 mM Tris-HCl, pH 7.5, 4 mM MgCl2, 10 mM β-mercaptoethanol. The reaction is carried out under conditions that the initial rate is within the linear kinetic range. The filter papers are then washed three times in 0.5% phosphoric acid, air-dried, and counted using a Beckman LS6500 multipurpose scintillation counter.
细胞实验	Cell proliferation was determined by counting the number of viable cells upon trypan blue staining. Cell proliferation is measured by CellTiter-Glo Luminescent Cell Viability Assay according to the manufacturer's instructions.(Only for Reference)

化学信息

分子量	217.22
分子式	C₁₂H₁₁NO₃
CAS No.	521937-07-5

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 65 mg/mL (299.24 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6036 mL	23.0181 mL	46.0363 mL	230.1814 mL
5 mM	0.9207 mL	4.6036 mL	9.2073 mL	46.0363 mL
10 mM	0.4604 mL	2.3018 mL	4.6036 mL	23.0181 mL
20 mM	0.2302 mL	1.1509 mL	2.3018 mL	11.5091 mL
50 mM	0.0921 mL	0.4604 mL	0.9207 mL	4.6036 mL
100 mM	0.0460 mL	0.2302 mL	0.4604 mL	2.3018 mL