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AJI-100是一种针对Aurora Kinase A和JAK2的双靶点抑制剂,其IC50值分别为12.7 nM和18.5 nM。该化合物通过抑制Aurora Kinase A实现对T细胞有丝分裂进程和细胞极性的调控,并通过阻断JAK2活性减少STAT3的磷酸化,从而抑制TH1和TH17细胞的分化。AJI-100主要用于研究调节免疫反应及防治移植物抗宿主病(GVHD)的应用潜力。
AJI-100是一种针对Aurora Kinase A和JAK2的双靶点抑制剂,其IC50值分别为12.7 nM和18.5 nM。该化合物通过抑制Aurora Kinase A实现对T细胞有丝分裂进程和细胞极性的调控,并通过阻断JAK2活性减少STAT3的磷酸化,从而抑制TH1和TH17细胞的分化。AJI-100主要用于研究调节免疫反应及防治移植物抗宿主病(GVHD)的应用潜力。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | AJI-100 serves as a dual-target inhibitor, effectively blocking Aurora kinase A and JAK2, with respective IC50 values of 12.7 nM and 18.5 nM. It inhibits T cell mitosis and cell polarity by directly targeting Aurora kinase A and reduces STAT3 phosphorylation by inhibiting JAK2 activation, consequently diminishing the differentiation of TH1 and TH17 cells. This compound is utilized in researching immune response regulation and the prevention of graft-versus-host disease (GVHD). |
分子量 | 323.32 |
分子式 | C17H14FN5O |
CAS No. | 844435-10-5 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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