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p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.
p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | 询价 | 35日内发货 | |
10 mg | 询价 | 35日内发货 | |
25 mg | 询价 | 35日内发货 |
产品描述 | p38 MAPK inhibitor IV is an ATP-competitive inhibitor of p38 MAP kinases with IC50 values of 0.13, 0.55, 5.47, and 8.63 μM for p38α, p38β, p38x, and p38δ, respectively, in vitro.[1] It also inhibits LPS-induced TNF-α and IL-1β cytokine production (IC50s = 22 and 44 nM, respectively) in human peripheral blood mononuclear cells. |
靶点活性 | p38δ:8.63 μM (IC50), p38α:0.13 μM (IC50), p38χ:5.47 μM (IC50), p38β:0.55 μM (IC50) |
别名 | p38 MAPK Inhibitor IV |
分子量 | 456.94 |
分子式 | C12H4Cl6O4S |
CAS No. | 1638-41-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: 2.5 mg/mL DMF: 2 mg/mL |
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