CRT0063465 is a ligand for both human Phosphoglycerate Kinase 1 (PGK1) and the stress sensor protein DJ-1, exhibiting a dissociation constant (Kd) of 24 μM for PGK1. Additionally, it influences the composition of the shelterin complex and modulates telomere length [1].

CRT0063465（10、100 nM，最长84天）抑制TCT116细胞在低血糖环境中的端粒缩短[1]。CRT0063465（10 nM, 1周）在非应激条件下调控HCT116细胞的庇护蛋白复合体组成[1]。在Bleomycin诱导的A2780细胞中，CRT0063465（100 nM，最高100小时）展现出对毒性的防护效应[1]。