Ilorasertib hydrochloride

Name: Ilorasertib hydrochloride
Brand: TargetMol
SKU: T11638
Price: 496 USD
Availability: InStock
Rating: 5 (10 reviews)

产品编号 T11638Cas号 1847485-91-9

别名 ABT-348 hydrochloride

Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).

Ilorasertib hydrochloride

纯度: 98.34%

产品编号 T11638 别名 ABT-348 hydrochlorideCas号 1847485-91-9

规格	价格	库存	数量
1 mg	¥ 496	现货

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纯度:98.34%

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产品介绍

生物活性

产品描述	Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
靶点活性	FLT3:1 nM, c-Kit:20 nM, Aurora A:120 nM, PDGFRβ:13 nM, Aurora B:7 nM, Aurora B (Y156H):12 nM, PDGFRα:11 nM, CSF1R:3 nM, Aurora C:1 nM, VEGFR1:1 nM, VEGFR3:43 nM, VEGFR2:2 nM
别名	ABT-348 hydrochloride

化学信息

分子量	525
分子式	C₂₅H₂₂ClFN₆O₂S
CAS No.	1847485-91-9

储存&溶解度

存储

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 41.67 mg/mL (79.37 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9048 mL	9.5238 mL	19.0476 mL	95.2381 mL
5 mM	0.3810 mL	1.9048 mL	3.8095 mL	19.0476 mL
10 mM	0.1905 mL	0.9524 mL	1.9048 mL	9.5238 mL
20 mM	0.0952 mL	0.4762 mL	0.9524 mL	4.7619 mL
50 mM	0.0381 mL	0.1905 mL	0.3810 mL	1.9048 mL