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MRT00033659
还可以产品编号 T16141Cas号 1401731-54-1
MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
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MRT00033659
还可以产品编号 T16141Cas号 1401731-54-1
MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 2 mg | ¥ 720 | 5日内发货 | |
| 5 mg | ¥ 1,230 | 5日内发货 | |
| 25 mg | ¥ 4,150 | 6-8周 | |
| 50 mg | ¥ 5,400 | 6-8周 | |
| 100 mg | ¥ 7,890 | 6-8周 |
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生物活性
化学信息
| 产品描述 | MRT00033659 is an effective broad-spectrum kinase inhibitor of CK1 (IC50=0.9 μM for CK1δ) and CHK1 (IC50=0.23 μM). MRT00033659 is a pyrazolo-pyridine analogue. It also induces p53 pathway activation and E2F-1 destabilization. |
| 靶点活性 | Chk1:0.23 μM, CKIδ:0.9 μM |
| 体外活性 | MRT00033659 does not inhibit p38α MAPK. MRT00033659 (1-80 μM; 48 hours) causes substantial cell death from 5 μM. MRT00033659 (0.2-80 μM; 48 hours) induces a robust and sustained stabilisation of p53, MDM2, and p21 proteins, as well as E2F-1 destabilisation from 0.2 μM to 5 μM. MRT00033659 (5-40 μM; 48 hours) is sufficient to obviously decrease cell number of 5 μM . |
| 分子量 | 266.3 |
| 分子式 | C15H14N4O |
| CAS No. | 1401731-54-1 |
| 密度 | 1.312 g/cm3 (Predicted) |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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