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NPD10084是一种丙酮酸激酶PKM2抑制剂,可抑制癌细胞中的非糖酵解信号。NPD10084中断PKM2和β-catenin或STAT3间相互作用,并抑制下游信号传导。NPD10084在体外和体内对结直肠癌细胞具有抗增殖活性。
NPD10084是一种丙酮酸激酶PKM2抑制剂,可抑制癌细胞中的非糖酵解信号。NPD10084中断PKM2和β-catenin或STAT3间相互作用,并抑制下游信号传导。NPD10084在体外和体内对结直肠癌细胞具有抗增殖活性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | NPD10084 is an inhibitor of pyruvate kinase PKM2 that blocks non-glycolytic signaling in cancer cells by disrupting PKM2's interaction with β-catenin or STAT3, thus inhibiting downstream pathways. It demonstrates antiproliferative effects against colorectal cancer cells both in vitro and in vivo [1]. |
分子量 | 345.39 |
分子式 | C21H19N3O2 |
CAS No. | 1040706-91-9 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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