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Anti-NTRK2 Monoclonal Antibody
产品编号 TMAZ-0205
别名 Tropomyosin-related kinase B, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase
Anti-NTRK2 Monoclonal Antibody is a rabbit antibody targeting NTRK2. Anti-NTRK2 Monoclonal Antibody can be used in ELISA, FACS.
Anti-NTRK2 Monoclonal Antibody
Anti-NTRK2 Monoclonal Antibody
产品编号 TMAZ-0205 别名 Tropomyosin-related kinase B, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase
Anti-NTRK2 Monoclonal Antibody is a rabbit antibody targeting NTRK2. Anti-NTRK2 Monoclonal Antibody can be used in ELISA, FACS.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 1,874 | 7日内发货 | |
| 50 μg | ¥ 2,248 | 7日内发货 | |
| 100 μg | ¥ 3,147 | 7日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-NTRK2 Monoclonal Antibody is a rabbit antibody targeting NTRK2. Anti-NTRK2 Monoclonal Antibody can be used in ELISA, FACS. |
| 别名 | Tropomyosin-related kinase B, GP145-TrkB, Neurotrophic tyrosine kinase receptor type 2, BDNF/NT-3 growth factors receptor, TrkB tyrosine kinase |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of NTRK2 overexpressed 485F cells with TMAZ-0205, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of NTRK2 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed: 15494731, PubMed: 7574684). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed: 15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | NTRK2 |
| 抗原种属 | Human |
| 基因ID | 4915 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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