Choerospondin, a dietary flavonoid glycoside isolated from the bark of the southern date palm (Ziziphus jujuba L.), is a potential α-glucosidase inhibitor with antiproliferative, antioxidant, antitumor, and anti-inflammatory activities that enhances the resistance to oxidative stress, and significantly inhibits inflammatory responses by attenuating mitogen-activated protein kinase phosphorylation and nuclear factor-κ B activation.