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Anti-AXL Monoclonal Antibody
产品编号 TMAZ-0122
别名 Tyrosine-protein kinase receptor UFO, AXL oncogene
Anti-AXL Monoclonal Antibody is a rabbit antibody targeting AXL. Anti-AXL Monoclonal Antibody can be used in ELISA, FACS, IF.
Anti-AXL Monoclonal Antibody
Anti-AXL Monoclonal Antibody
产品编号 TMAZ-0122 别名 Tyrosine-protein kinase receptor UFO, AXL oncogene
Anti-AXL Monoclonal Antibody is a rabbit antibody targeting AXL. Anti-AXL Monoclonal Antibody can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 925.68¥ 1,596 | 7日内发货 | |
| 50 μg | ¥ 1,110.7¥ 1,915 | 7日内发货 | |
| 100 μg | ¥ 1,554.4¥ 2,680 | 7日内发货 |
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产品介绍
生物活性
偶联与修饰
抗原信息
化学信息
| 产品描述 | Anti-AXL Monoclonal Antibody is a rabbit antibody targeting AXL. Anti-AXL Monoclonal Antibody can be used in ELISA, FACS, IF. |
| 别名 | Tyrosine-protein kinase receptor UFO, AXL oncogene |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of AXL overexpressed 312F cells with TMAZ-0122, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of AXL protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, AXL binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3; but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TNS2. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response|(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope|(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope|(Microbial infection) Promotes Zika virus entry in glial cells, Sertoli cells and astrocytes (PubMed: 28076778, PubMed: 29379210, PubMed: 31311882). Additionally, Zika virus potentiates AXL kinase activity to antagonize type I interferon signaling and thereby promotes infection (PubMed: 28076778). Interferon signaling inhibition occurs via an SOCS1-dependent mechanism (PubMed: 29379210) |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | AXL |
| 抗原种属 | Human |
| 基因ID | 558 |
| Uniprot ID | |
| 研究领域 | Cancer Research |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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