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IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 抑制剂(IC50:7 nM)。
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IRAK4-IN-1 是白细胞介素-1 受体相关激酶 4 抑制剂(IC50:7 nM)。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 641 | 现货 | |
5 mg | ¥ 1,580 | 现货 | |
10 mg | ¥ 2,390 | 现货 | |
25 mg | ¥ 3,960 | 现货 | |
50 mg | ¥ 5,760 | 现货 | |
100 mg | ¥ 7,860 | 现货 | |
500 mg | ¥ 15,800 | 现货 |
产品描述 | IRAK4-IN-1 is an interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor with an IC50 of 7 nM. |
靶点活性 | IRAK4:7 nM. |
体外活性 | IRAK4-IN-1的体外代谢稳定性特征已测定,其在大鼠全血(RWB)中的EC50值为2300 nM。 |
体内活性 | 口服药代动力学研究表明,IRAK4-IN-1具有高生物利用度,为73%,并且其血浆清除率较低(Clp=22 mL/min/kg),从而导致了相对合理的半衰期,为1.3小时。 |
动物实验 | In the TLR driven in vivo model, female Lewis rats are dosed with either vehicle or IRAK4-IN-1 (Compound 23; 3, 10, 30, and 100 mg/kg; p.o.) dosed at 1 h prior to stimulation with Resiquimod, R848 (5 mg/kg, IP). At 1.5 h post R848 stimulation, blood samples are obtained from the animals and cytokine levels are measured. |
分子量 | 337.42 |
分子式 | C19H23N5O |
CAS No. | 1820787-94-7 |
Smiles | N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1 |
密度 | 1.26 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: 1 mg/ml, Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) |
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