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IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力 。
IQ-1S free acid (IQ-1S) 是 NF-κB/激活蛋白1 (AP-1) 抑制剂(IC50:2.3±0.41 μM)。它对 JNK1(Kd:240 nM)、JNK2(Kd:360 nM) 和 JNK3(Kd:100 nM)的都具有高的结合亲和力 。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 183 | In stock | |
5 mg | ¥ 397 | In stock | |
10 mg | ¥ 512 | In stock | |
25 mg | ¥ 947 | In stock | |
50 mg | ¥ 1,620 | In stock | |
100 mg | ¥ 2,670 | In stock | |
200 mg | ¥ 3,880 | In stock | |
1 mL x 10 mM (in DMSO) | ¥ 397 | In stock |
产品描述 | IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can serve as a small-molecule modulator for mechanistic studies of JNK function in rheumatoid arthritis. IQ-1S is highly specific for JNK and that its neutral form is the most abundant species at physiologic pH. |
靶点活性 | PI3Kγ:0.47 μM (Kd), JNK2:360 nM (Kd), JNK3:100 nM (Kd), JNK1:240 nM (Kd), CK1δ:0.38 μM (Kd), NF-κB:2.3±0.41 μM, MKNK2:0.92 μM (Kd) |
别名 | IQ-1S (free acid), IQ-1S, IQ-1 |
分子量 | 247.25 |
分子式 | C15H9N3O |
CAS No. | 23146-22-7 |
Smiles | ON=C1c2ccccc2-c2nc3ccccc3nc12 |
密度 | no data available |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 18.33 mg/mL (74.15 mM), Sonication is recommended. ![]() | ||||||||||||||||||||||||||||||
溶液配制表 | |||||||||||||||||||||||||||||||
DMSO
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以上为“体内实验配液计算器”的使用方法举例,并不是具体某个化合物的推荐配制方式,请根据您的实验动物和给药方式选择适当的溶解方案。
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