IQ-1S free acid (IQ-1S) is an effective and specific c-Jun N-Terminal Kinase Inhibitor. IQ-1S inhibits murine delayed-type hypersensitivity. IQ-1S can reduce inflammation and cartilage loss associated with CIA and can serve as a small-molecule modulator for mechanistic studies of JNK function in rheumatoid arthritis. IQ-1S is highly specific for JNK and that its neutral form is the most abundant species at physiologic pH.

NF-κB:2.3±0.41 μM, PI3Kγ:0.47 μM (Kd), JNK3:100 nM (Kd), CK1δ:0.38 μM (Kd), JNK2:360 nM (Kd), JNK1:240 nM (Kd), MKNK2:0.92 μM (Kd)