Rebeccamycin

产品编号 T16726Cas号 93908-02-2

别名

Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.

Rebeccamycin

产品编号 T16726Cas号 93908-02-2

规格	价格	库存	数量
500 μg	¥ 2,970	35日内发货
2500 μg	¥ 13,800	35日内发货

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产品介绍

生物活性

产品描述	Rebeccamycin is an antitumor antibiotic+ inhibits DNA topoisomerase I. Rebeccamycin appears to exert its primary antineoplastic effect by poisoning topoisomerase I. It also has a negligible effect on protein kinase C and topoisomerase II.
体外活性	Rebeccamycin produced by the actinomycete Saccharotrix aerocolonigenes. It has activity against several human tumor cell lines, including lung adenocarcinoma, colon carcinoma, and nasopharyngeal carcinoma. Rebeccamycin displays antibacterial activity against several Gram-positive bacteria, including Staphylococcus aureus and Streptococcus faecalis [1][3].
体内活性	Rebeccamycin (2-256 mg/kg; i.p.; daily for 9 days) prolongs survival in B16 melanoma and L1210 leukemia[2].