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TPPB 是可渗透细胞的苯并内酰胺衍生蛋白的激酶 C 激活剂,Ki 值为11.9 nM。
TPPB 是可渗透细胞的苯并内酰胺衍生蛋白的激酶 C 激活剂,Ki 值为11.9 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,650 | 现货 | |
5 mg | ¥ 3,970 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 5,920 | 现货 |
产品描述 | TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM). |
靶点活性 | PKC:11.9 nM (ki) |
体外活性 | TPPB inhibits the activation of caspase-3 induced by Aβ25-35. TPPB could increase the phosphorylation of Akt, PKC, MARCKS, and MAPK, which are inhibited by Aβ25-35 treatment. TPPB at a concentration of 1 μM could antagonize Aβ25-35 induced cell damage. By the use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells [1][2]. |
体内活性 | TPPB is evaluated for the induction of hyperplasia displays a modest response at 300 μg after topical application to the shaved backs of outbred Sencar mice and [1]. |
分子量 | 501.54 |
分子式 | C27H30F3N3O3 |
CAS No. | 497259-23-1 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 125 mg/mL (249.23 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
DMSO
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