GSK2636771

产品编号 T2073Cas号 1372540-25-4

别名 GSK 2636771|||GSK-2636771

GSK2636771 是选择性的、口服有效的PI3Kβ抑制剂，Ki=0.89 nM，IC50=5.2 nM，比p110α和p110γ的选择性高900倍，比p110δ同种型的选择性高10倍。

为众多的药物研发团队赋能，

让新药发现更简单！

GSK2636771

产品编号 T2073别名 GSK 2636771, GSK-2636771Cas号 1372540-25-4

GSK2636771 是选择性的、口服有效的PI3Kβ抑制剂，Ki=0.89 nM，IC50=5.2 nM，比p110α和p110γ的选择性高900倍，比p110δ同种型的选择性高10倍。

规格	价格	库存
1 mg	¥ 413	现货
5 mg	¥ 987	现货
10 mg	¥ 1,550	现货
25 mg	¥ 2,530	现货
50 mg	¥ 3,650	现货
100 mg	¥ 5,390	现货
500 mg	¥ 10,900	现货
1 mL x 10 mM (in DMSO)	¥ 1,130	现货

大包装 & 定制

加入购物车

实验操作小课堂

"GSK2636771"的相关化合物库

选择批次:

纯度:99.74%

联系我们获取更多批次信息

资源下载

COA HPLC HNMR 产品操作手册

TargetMol 的所有产品仅用作科学研究或药证申报，不能被用于人体，我们不向个人提供产品和服务。请您遵守承诺用途，不得违反法律法规规定用于任何其他用途。

产品介绍

生物活性

产品描述	GSK2636771, an effective, specific, orally bioavailable, PI3Kβ inhibitor, has been used in cancer, lymphoma, solid neoplasm, recurrent solid neoplasm, and advanced malignant neoplasm.
靶点活性	PI3Kβ:5.2 nM
体外活性	在小鼠中,GSK-2636771 （100 mg/kg）不增加葡萄糖/胰岛素水平.在移植瘤模型中,GSK-2636771降低磷酸化的蛋白激酶Akt（Ser473）水平.
体内活性	在PTEN缺失细胞系中,GSK-2636771具有特异的抑制活性,在人前列腺癌PC-3（EC50=36 nM）和乳腺癌HCC70（EC50=72 nM）。
细胞实验	Cells are plated in 96-well microtiter plates at densities ranging from 1,500 to 15,000 cells/well, optimized for untreated control cells to be 80-90% confluent at the endpoint of the experiment. After 24 h, cells are treated with serial dilutions (100pM to 10μM) of GSK2636771. Cell viability is assessed after 72 h of treatment by incubation with CellTiter Blue for 1.5 h. The drug concentration requires for survival of 50% of cells relative to untreated cells (surviving fraction 50, SF50) is determined using GraphPad Prism version 5.0d. Cell lines that fails to achieve the SF50 to a given drug are nominally assigned as the highest concentration screened (i.e. 10μM). At least three independent experiments in triplicate per cell line targeted drug are performed. Association between a mutation and response to a targeted agent is determined using a Fisher’s exact test (GraphPad Prism), and a two-tailed P value <0.05 is considered statistically significant. (Only for Reference)
别名	GSK 2636771, GSK-2636771

化学信息

分子量	433.42
分子式	C₂₂H₂₂F₃N₃O₃
CAS No.	1372540-25-4

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 9 mg/mL (20.77 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3072 mL	11.5362 mL	23.0723 mL	115.3615 mL
5 mM	0.4614 mL	2.3072 mL	4.6145 mL	23.0723 mL
10 mM	0.2307 mL	1.1536 mL	2.3072 mL	11.5362 mL
20 mM	0.1154 mL	0.5768 mL	1.1536 mL	5.7681 mL