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KN-93 hydrochloride 是一种具有细胞渗透性,可逆和竞争性的钙调蛋白依赖性激酶II 型 (CaMKII) 抑制剂,Ki 为370 nM。
KN-93 hydrochloride 是一种具有细胞渗透性,可逆和竞争性的钙调蛋白依赖性激酶II 型 (CaMKII) 抑制剂,Ki 为370 nM。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 668 | 5日内发货 |
产品描述 | KN-93 hydrochloride is a cell-permeable, reversible and competitive calmodulin-dependent kinase type II ( CaMKII ) inhibitor with a K i of 370 nM. |
体外活性 | After 2 days of KN-93 treatment, 95% of cells are arrested in G1. G1 arrest is reversible; 1 day after KN-93 release, a peak of cells had progressed into S and G2-M. In addition, KN-93 also blocks cell growth stimulated by basic fibroblast growth factor, platelet-derived growth factor-BB, and epidermal growth factor in NIH 3T3 fibroblasts [1]. KN-93 inhibits the H +, K + -ATPase activity but strongly dissipates the proton gradient formed in the gastric membrane vesicles and reduces the volume of luminal space [2]. KN-93 (0.5 μM) prevents increased LV developed pressure during action potential prolongation and early afterdepolarizations. Ca 2+ -independent CaM kinase activity is increased during early afterdepolarizations and this increase is prevented by KN-93 [3]. |
分子量 | 537.5 |
分子式 | C26H30Cl2N2O4S |
CAS No. | 1956426-56-4 |
密度 | 1.31g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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