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Anti-TYRO3 Monoclonal Antibody
产品编号 TMAZ-0193
别名 Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase TIF, Tyrosine-protein kinase BYK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase DTK
Anti-TYRO3 Monoclonal Antibody is a rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody can be used in ELISA, FACS, IF.
Anti-TYRO3 Monoclonal Antibody
Anti-TYRO3 Monoclonal Antibody
产品编号 TMAZ-0193 别名 Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase TIF, Tyrosine-protein kinase BYK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase DTK
Anti-TYRO3 Monoclonal Antibody is a rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody can be used in ELISA, FACS, IF.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 25 μg | ¥ 725¥ 1,250 | 7日内发货 | |
| 50 μg | ¥ 870¥ 1,500 | 7日内发货 | |
| 100 μg | ¥ 1,217.42¥ 2,099 | 7日内发货 |
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产品介绍
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偶联与修饰
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| 产品描述 | Anti-TYRO3 Monoclonal Antibody is a rabbit antibody targeting TYRO3. Anti-TYRO3 Monoclonal Antibody can be used in ELISA, FACS, IF. |
| 别名 | Tyrosine-protein kinase receptor TYRO3, Tyrosine-protein kinase TIF, Tyrosine-protein kinase BYK, Tyrosine-protein kinase RSE, Tyrosine-protein kinase SKY, Tyrosine-protein kinase DTK |
| Ig Type | Rabbit monoclonal IgG |
| 交叉反应 | Human |
| 验证活性 | Flow cytometry analysis of TYRO3 overexpressed 295F cells with TMAZ-0193, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| 应用 | ELISA, FACS, IF |
| 推荐剂量 | 0.1-0.2 μg/10E6 cells for FACS; 1 ng/μl for ELISA |
| 抗体种类 | Monoclonal |
| 宿主来源 | Rabbit |
| 亚细胞定位 | Single-pass type I membrane |
| 构建方式 | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of TYRO3 protein. |
| 纯化方式 | Protein A Affinity Purified |
| 性状 | Liquid |
| 缓冲液 | 0.22 μm filtered solution in 20 mM HEPES7.4, 150 mM NaCl, 50% glycerol and 0.03% proclin. |
| 纯度 | > 95% as determined by SDS-PAGE. |
| 研究背景 | Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3|(Microbial infection) Acts as a receptor for lassa virus and lymphocytic choriomeningitis virus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope|(Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope |
| 偶联 | Unconjugated |
| 其他可选修饰符 | Biotin/APC/PE/AF488/AF555/AF647 |
| 可提供抗体种类 | 1 |
| 免疫原 | TYRO3 |
| 抗原种属 | Human |
| 基因ID | 7301 |
| Uniprot ID | |
| 研究领域 | Drug Target |
| 分子量 | 150 kDa |
存储&运输
| 储存方式 | For unconjugated and biotin antibody, store at -20°C or -80°C for long term. Avoid repeated freeze-thaw cycles. For APC/PE/AF647/AF555/AF488 conjugated antibody, store at 4°C, do not freeze. |
| 运输方式 | For unconjugated and biotin antibody, shipping with dry ice. For APC/PE/AF647/AF555/AF488 conjugated antibody, shipping with blue ice. |
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