NDBM, a tumor-specific probe that targets Pim-1 kinase, exhibits heightened fluorescence upon binding and induces cytotoxicity, facilitating both cell screening and killing. It possesses targeted action on lysosomes and a sensitive pH response, enabling the monitoring of intracellular pH variations associated with autophagy and external stimuli [1].

NDBM在正常细胞系（HUVEC、RAW 264.7）中的荧光强度不及肿瘤细胞系（MGC-803、HepG2 和 Hela）[1]。此外，NDBM处理（2.5、5、10和20 μM, 18小时）能显著降低MGC-803、HepG2 和 Hela肿瘤细胞的存活率 [1]。