5hydroxydecanoate sodium

5-Hydroxydecanoate sodium 是一种选择性 ATP 敏感的 K+ (KATP) 通道阻滞剂，IC50 约为 30 μM。 它是线粒体外膜酰基辅酶A 合成酶的底物，具有抗氧化性。

Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸，是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。

Glyceryl 5-hydroxydecanoate is a flavor and Fragrance Chemical Compounds.

Xanthosine 5'-monophosphate sodium salt (L-XMP Sodium) 是嘌呤代谢的一种中间体。它可用于研究遗传密码，核酸结构以及 DNA，RNA 和蛋白质合成。

7-Deazaadenosine-5'-O-diphosphate是一种修饰过的核苷酸和tubercidin的代谢物。该化合物通过磷酸化tubercidin形成，并进一步磷酸化生成活性代谢物7-deazaadenosine-5'-O-triphosphate。

GDP-β-L-fucose is a metabolite in plant and animal. It used for microbe agglutination assay and agglutination inhibition assay. GDP-β-L-fucose is formed by the oxidation-reduction and epimerization of GDP-R-D-mannose in most organisms.

5-Phospho-D-ribose 1-diphosphate (PRPP) is a natural intermediate involved in the pentose phosphate pathway leading to purine, pyrimidine, and histidine metabolism. It is also an intermediate in the synthesis of plant hormones, alkaloids, and other secondary metabolites from glucose. Several phosphoribosyltransferases (PRTases) use PRPP as a substrate to add a 5-phosphoribosyl group to another substrate, as in the production of adenosine monophosphate from adenine and PRPP by adenine PRTase. N/A

7-Methylguanosine 5’-diphosphate (7-Methyl-GDP) sodium, a cap analog, can be used in the synthesis of mRNA cap analogues[1]. 7-Methylguanosine 5’-diphosphate sodium inhibits binding of eukaryotic initiation factors to reovirus capped mRNA and complex formation involving uncapped mRNA or 18 S rRNA[1].T. brucei mRNA decapping enzyme (TbDcp2) that cleaves 7-Methylguanosine 5’-diphosphate sodium from capped RNA to generate pRNA, a substrate for TbCe1[2]. [1]. Sonenberg N, et al. Nonspecific effect of m7GMP on protein-RNA interactions. J Biol Chem. 1978;253(19):6630-6632.[2]. Ignatochkina AV, et al. The messenger RNA decapping and recapping pathway in Trypanosoma. Proc Natl Acad Sci U S A. 2015;112(22):6967-6972.

Adenosine 5′-monophosphoramidate sodium is a derivative of adenosine used as an intermediate for nucleotide synthesis. It significantly influences the accumulation of cyclic AMP.

3'-O-Methylguanosine-5'-O-triphosphate（3'-O-methyl GTP）是GTP的甲基化衍生物，用作早期RNA聚合酶II延伸中间体制备中的链终止试剂。

Uridine 5’-methylenediphosphate (UMP-CP) 是 purinergic P2Y14 受体的激动剂，同时也是 UDP 的一种水解稳定衍生物。它在表达人类 P2Y14 的细胞中选择性地抑制 cAMP 产生，相较于表达人类 P2Y6 的细胞（EC50s 分别为 11 和 339 nM）。

Sp-2'-Deoxycytidine-5'-O-(1-thiotriphosphate) (Sp-dCTP-α-S) 是含硫核苷酸衍生物 dCTP-α-S 的异构体。它抑制解氧核苷酸三磷酸三磷酸水解酶 SAMHD1（Ki = 6.3 µM）。

Rp-2'-Deoxyuridine-5'-O-(1-thiotriphosphate) (Rp-dUTP-α-S) 是含硫核苷酸 dUTP-α-S 的同分异构体，也是嘌呤P2Y2受体的激动剂。在表达P2Y2受体的1321N1星形胶质瘤细胞中，该化合物特异性诱导肌醇磷酸积累（EC50 = 12.5 µM），相较于表达P2Y4的1321N1细胞，在10 µM浓度下效果更显著。

Rp-Uridine-5'-O-(1-thiotriphosphate)（Rp-UTP-α-S）是一种核苷酸激动剂，针对嘌呤P2Y2和P2Y4受体。在表达P2Y2或P2Y4受体的1321N1星形胶质细胞中，它能够促进肌醇磷酸的积累（EC50s分别为5.4 和27 µM）。

6-Chloropurine riboside-5'-triphosphate是一种RNA三磷酸酶mRNA-帽化酶β亚单位(Cet1; IC50 = 2 µM，针对S. cerevisiae酶的GTPase活性)的抑制剂，同时也是6-chloropurine riboside的磷酸化形式。此外，它还能激活E. coli天冬氨酸氨甲酰转移酶(EC50 = 0.76 mM)。6-Chloropurine riboside-5'-triphosphate已在合成具有抗癌活性的细胞因子以及一种光点击形式的ATP中得到应用。

Adenosine 2',5'-diphosphate sodium is a competitive P2Y1 antagonist with non-selective antagonism at recombinant and human platelet P2X1 receptors.

5-BrUTP sodium salt can be used to label RNA to measure the transcription.

Intermediates and Building Blocks - Nucleophile, Electrophile; Fine Chemical

Adenosine 3',5'-diphosphate sodium salt 是一种羟类固醇磺基转移酶 (hydroxysteroid sulfotransferases) 抑制剂，是一种腺嘌呤核苷酸，在戊糖核糖的 3'和 5'位置含有一个磷酸基团。Adenosine 3',5'-diphosphate (sodium salt)是 3'-phosphoadenosine 5'-phosphosulfonate (PAPS) 的产物，是磺基转移酶（SULTs）的辅助因子，已被用于研究 SULTs 的动力学特性和结构。

Rp-Adenosine-5'-O-(1-thiotriphosphate)（Rp-ATP-α-S）是一种含硫核苷酸衍生物ATP-α-S的异构体，同时也是嘌呤P2Y1受体的激动剂。在表达人类P2Y1受体的HEK293细胞中，Rp-ATP-α-S能增加钙的动员（EC50 = 75 nM）。该化合物与洗涤的人类孤立血小板结合（Ki = 156 nM），抑制由ADP引发的人类富血小板血浆（PRP）的聚集（pA2 = 4.74），并且能够抑制前列腺素E1（PGE1）在人类孤立PRP中引发的cAMP产生（pA2 = 5.26）。同时，Rp-ATP-α-S还能引起用氨基甲酰胆碱预先缩紧的豚鼠结肠条带的松弛（EC50 = 56 nM）。此外，Rp-ATP-α-S已经被用于合成被细菌核糖开关识别的环状二核苷酸。

2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate是ATP的一种氟代衍生物，ATP是细胞代谢必需的能量底物。它抑制E. coli RNA聚合酶(Ki = 200 µM)。

Isoguanosine-5'-O-diphosphate (isoGDP)，是GDP的一个异构体，也是crotonoside的一种磷酸化形式。isoGDP能抑制线粒体ATPase（IC50 = 3 µM）。

Sp-2'-Deoxyguanosine-5'-O-(1-thiotriphosphate) 是一种含硫异构体，属于核苷酸三磷酸2'-脱氧鸟苷-5'-O-三磷酸(dGTP)。它通过抑制脱氧核苷酸三磷酸三磷酸水解酶SAMHD1 (Ki = 820 nM)发挥作用。

TMP-CP（Thymidine-5’-O-(α,β-methylene)diphosphate）是TDP的一种水解稳定衍生物，同时也是一种thymidine kinase抑制剂（Ki = 23 µM）。它已被用作α,β-methylene-2’-deoxythymidine 5’-triphosphate合成的前体，该合成物是DNA polymerase的一种不可切割底物。

substrate of IMP dehydrogenase (IMPDH)

7-Methyl-guanosine-5'-triphosphate (m7GTP) sodium 是一种鸟苷 5'-磷酸。7-Methyl-guanosine-5'-triphosphate sodium 的硫代磷酸酯类似物是一种强效的 cap-dependent 翻译抑制剂。

Sodium ((2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl diphosphate 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T65217。

5′-Guanylyl methylenediphosphonate (sodium) 为GTP类似物，充当蛋白质合成中GTP反应的特异性竞争性抑制剂。

2-Chloroadenosine-5'-O-diphosphate是一种腺苷5'二磷酸（ADP）的衍生物。它在浓度依赖性的方式下，促进了人类富含血小板的血浆中的聚集，并抑制了由前列腺素E2（PGE2）诱导的环磷酸腺苷（cAMP）的产生。2-Chloroadenosine-5'-O-diphosphate引起预收缩的孤立的豚鼠taenia coli条带放松（pD2 = 6.74），降低大鼠的动脉血压。此外，它还抑制了热休克蛋白70（Hsp70）家族成员mortalin的ATP酶活性（人类酶的表观Ki = 45.05 µM）。

5'-pApA is a linearized form of cyclic di-AMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3,4It is a metabolite of cyclic di-AMP formedviahydrolysis by various phosphodiesterases (PDEs).55'-pApA is intended for use as a negative control for cyclic di-AMP signaling. 1.Burdette, D.L., Monroe, K.M., Sotelo-Troha, K., et al.STING is a direct innate immune sensor of cyclic-di-GMPNature478(7370)515-518(2011) 2.Parvatiyar, K., Zhang, Z., Teles, R.M., et al.DDX41 recognizes bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune responseNat. Immunol.13(12)1155-1161(2012) 3.Woodward, J.J., Iavarone, A.T., and Portnoy, D.A.c-di-AMP secreted by intracellular Listeria monocytogenes activates a host type I interferon responseScience328(5986)1703-1705(2010) 4.Witte, C.E., Whiteley, A.T., Burke, T.P., et al.Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infectionmBio4(3)e00282-00213(2013) 5.Fahmi, T., Port, G.C., and Cho, K.H.c-di-AMP: An essential molecule in the signaling pathways that regulate the viability and virulence of gram-positive bacteriaGenes (Basel)8(8)197(2017)

Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种烟酰胺腺嘌呤核苷酸 (NAD+) 的代谢产物，广泛存在于生物体内。Adenosine 5'-diphosphoribose sodium (ADP ribose sodium) 是一种高效的细胞内 Ca2+ 渗透性阳离子 TRPM2 通道激活剂，还可以诱导自噬 (autophagy)。

Uridine-5'-O-(3-thiotriphosphate) (UTP-γ-S) 是UTP的一种抗水解衍生物，是嘌呤P2Y2受体的激动剂。在表达人类P2Y2受体的1321N1星形胶质瘤细胞中，其可诱导肌醇磷酸盐的形成（EC50 = 240 nM），并且在来自囊性纤维化患者的原代鼻上皮细胞中以浓度依赖的方式诱导氯离子分泌。UTP-γ-S在分离的人类冠状动脉中诱导血管收缩（EC50 = 25.1 µM）。

Isoguanosine-5'-O-triphosphate是guanosine 5'-triphosphate（GTP）的一个异构体且是crotonoside的磷酸化形式。与GTP不同，Isoguanosine-5'-O-triphosphate不促进微管组装。在逆转录酶实验中，Isoguanosine-5'-O-triphosphate（2 mM）能抑制转录并诱导T到C的突变。它已被用于确定phosphofructokinase和mutT homolog 1（MTH1）的底物特异性。

Adenosine-5'-O-(3-thiotriphosphate)（ATPγS）是一种purinergic P2Y11受体的激动剂。在表达人类或犬类P2Y11受体的CHO-K1细胞中，能够诱导肌醇磷酸累积（EC50s分别为1.2和19.3 µM）。ATPγS（10 µM）能抑制Junin病毒导致的编码骨形态生成蛋白6（BMP6）的mRNA水平增加，并减少Junin病毒感染的初代大鼠成骨细胞中的粒子形成单位（PFUs）。使用25 µM浓度时，可以诱导MIN6胰岛β细胞分泌胰岛素。

Sp-Thymidine-5'-O-(1-thiotriphosphate)（Sp-TTP-α-S）是含硫核苷酸衍生物TTP-α-S的一个异构体。它能够结合HIV-1逆转录酶（在镁、锰酸盐和钴存在时，Kds分别为2.88、4.23和20.21 µM）。Sp-TTP-α-S抑制脱氧核苷酸三磷酸三磷酸水解酶SAMHD1（Ki为46 nM）。

Sp-Adenosine-5'-O-(1-thiotriphosphate) (Sp-ATP-α-S) 是一种含硫核苷酸衍生物 ATP-α-S 的异构体，也是嘌呤P2Y1受体的激动剂。在表达P2Y1受体的HEK293细胞中增加钙离子的流动（对人类受体的EC50 = 9.4 nM）。Sp-ATP-α-S 抑制了ADP诱导的孤立人类血小板聚集（Ki = 4 μM）。它还能引起经卡巴胆碱预收缩的豚鼠十二指肠松弛（EC50 = 426 nM）。

8-Chloroadenosine-5’-triphosphate（8-chloro ATP）是抗癌剂8-chloro cAMP的活性代谢物，也是核苷酸腺苷5’-三磷酸（ATP）的衍生物。它通过8-chloro cAMP、8-chloroadenosine以及一磷酸和二磷酸中间体形成。应用8-chloro cAMP或8-chloroadenosine后，8-chloro ATP可累积长达12小时，与细胞生长抑制、内源性ATP水平下降以及患者源多发性骨髓瘤细胞中RNA合成减少（但DNA合成不受影响）相关。在1.5至8 mM浓度范围内，它抑制topoisomerase II-α依赖的超螺旋pUC19 DNA放松，同时在1 mM时减少了K562人髓性白血病细胞中topoisomerase II-α催化的ATP水解50%。

Guanosine 5’-diphosphate (GDP) is a purine nucleotide and biosynthetic precursor of guanosine 5’-triphosphate .1It has been used to study the conformations of GTPases.2GDP (100 μM) activates sulfonylurea receptor 2B (SUR2B) linked to the inward-rectifier potassium channel 6.1 (Kir6.1) in HEK293T cells in a patch-clamp assay.3 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Biochemistry(2002) 2.Vetter, I.R., and Wittinghofer, A.The guanine nucleotide-binding switch in three dimensionsScience294(5545)1299-1304(2001) 3.Yamada, M., Isomoto, S., Matsumoto, S., et al.Sulphonylurea receptor 2B and Kir6.1 form a sulphonylurea-sensitive but ATP-insensitive K+ channelJ. Physiol.499(Pt 3)715-720(1997)

Uridine-5’-monophosphate (UMP) is a ribonucleotide.1It is formedviadecarboxylation of orotidine-5’-monophosphate (5’-OMP) by OMP decarboxylase. UMP is further phosphorylated by UMP-CMP kinase to form UDP and UTP during nucleic acid biosynthesis. Formulations containing UMP have been used as dietary supplements. 1.Berg, J.M., Tymoczko, J.L., and Stryer, L.Nucleotide BiosynthesisBiochemistry(2002)

Uridine-5'-diphosphoglucuronic acid is a nucleoside diphosphate sugar that is a source of glucuronic acid for polysaccharide biosynthesis. This compound can be used for the formation of many glucuronides with various aglycones.1 1.Green, M.D., and Tephly, T.R.Glucuronidation of amine substrates by purified and expressed UDP-glucuronosyltransferase proteinsDrug Metab. Dispos.26(9)860-867(1998)

Ethyl 5-hydroxydecanoate is flavor and Fragrance Chemical Compounds.

Riboflavin 5'-monophosphate (FMN) is a coenzyme that is tightly bound to enzymes catalyzing oxidation and reduction reactions in a variety of biosynthetic pathways. FMN also binds the FMN riboswitch (RFN element) on RNA to alter gene regulation. FMN is a substrate of FMN phosphohydrolases and is used to study their function.

5-BrdUTP sodium salt is a TdT substrate used for labeling DNA double-strand breaks.

Uridine 5'-diphosphate sodium salt is a selective native agonist of the P2Y6 receptor (EC50: 300 nM; pEC50: 6.52) and a potent antagonist of P2Y14 (pEC50: 7.28).

2’-O-甲基鸟苷-5'-O-三磷酸（2’-methyl GTP）作为丙肝病毒（HCV）非结构蛋白5B（NS5B；IC50 = 3.5 µM）的抑制剂，同时是前药IDX184的活性代谢产物，通过2’-methylguanosine中间体生成。在50 µM浓度下，2’-methyl GTP还能促进微管蛋白聚合。患有肝细胞癌的患者体内2’-methyl GTP水平，相比于邻近正常组织有所下降。

Sp-Guanosine-5'-O-(1-thiotriphosphate) (Sp-GTP-α-S) 是一种含硫核苷酸衍生物GTP-α-S的异构体。它能结合到微管蛋白上，在20 mM的浓度下用于无细胞实验时可诱导微管组装。

5'-pGpG is a linearized form of cyclic di-GMP, a bacterial second messenger that activates the host innate immune system through stimulator of interferon genes (STING).1,2,3It is a metabolite of cyclic di-GMP formedviahydrolysis by various phosphodiesterases (PDEs) that binds to the cyclic di-GMP-I riboswitch with reduced affinity compared to cyclic di-GMP.4,55'-pGpG is intended for use as a negative control for cyclic di-GMP signaling.

D-Ribulose-5-phosphate sodium salt (Ru5P sodium salt) 是在磷酸戊糖途径中产生的化合物，参与机体糖代谢和能量代谢，可用于合成脂多糖和氨基酸。