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Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) 是 Clofarabine-5'-diphosphate 的钠盐。Clofarabine 经脱氧胞苷激酶 (dCK) 磷酸化后生成 Clofarabine-5'-diphosphate trisodium,这个代谢产物能够进一步被磷酸化为 Clofarabine-5'-triphosphate,并在癌细胞中通过抑制 DNA 合成及 DNA 修复显现细胞毒性。
Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) 是 Clofarabine-5'-diphosphate 的钠盐。Clofarabine 经脱氧胞苷激酶 (dCK) 磷酸化后生成 Clofarabine-5'-diphosphate trisodium,这个代谢产物能够进一步被磷酸化为 Clofarabine-5'-triphosphate,并在癌细胞中通过抑制 DNA 合成及 DNA 修复显现细胞毒性。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | Clofarabine-5'-diphosphatetrisodium (Clofarabine-DP trisodium) is the sodium salt form of Clofarabine-5'-diphosphate. As a metabolic product of Clofarabine, it results from phosphorylation by deoxycytidine kinase (dCK). Clofarabine-5'-diphosphate trisodium can undergo further phosphorylation to form Clofarabine-5'-triphosphate, demonstrating cytotoxicity in cancer cells by inhibiting DNA synthesis and repair. |
别名 | Clofarabine-DP trisodium |
分子量 | 529.58 |
分子式 | C10H10ClFN5Na3O9P2 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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