SMU127

Name: SMU127
Brand: TargetMol
SKU: T35672
Price: 137 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T35672Cas号 903864-87-9

SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.

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产品编号 T35672Cas号 903864-87-9

SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.

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产品介绍

生物活性

产品描述	SMU127 is an agonist of the toll-like receptor 1/2 (TLR1/2) heterodimer.
体外活性	It induces NF-κB signaling in cells expressing human TLR2 (EC50= 0.55 μM) but not cells expressing human TLR3, -4, -5, -7, or -8 when used at concentrations ranging from 0.1 to 100 μM. SMU127 induces the production of TNF-α in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 0.01 to 1 μM.
体内活性	In vivo, SMU127 (0.1 mg/animal) reduces tumor volume in a 4T1 murine mammary carcinoma model.

化学信息

储存&溶解度

存储	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度信息	DMF:PBS (pH 7.2) (1:4): 0.20 mg/mL DMSO: Slightly soluble DMF: 1 mg/mL