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HDAC3-IN-5 (9c) 作为一种高选择性的HDAC3抑制剂,其IC50值在HDAC3、HDAC2 和HDAC1 对应为4.2 nM、1629 nM 和 298.2 nM.该化合物能有效在体外诱导MV4-11细胞的凋亡并减少抗凋亡蛋白的表达.因此,作为HDAC3的选择性抑制剂,HDAC3-IN-5 (9c) 有潜力成为针对Venetoclax耐药性逆转的先导化合物.
HDAC3-IN-5 (9c) 作为一种高选择性的HDAC3抑制剂,其IC50值在HDAC3、HDAC2 和HDAC1 对应为4.2 nM、1629 nM 和 298.2 nM.该化合物能有效在体外诱导MV4-11细胞的凋亡并减少抗凋亡蛋白的表达.因此,作为HDAC3的选择性抑制剂,HDAC3-IN-5 (9c) 有潜力成为针对Venetoclax耐药性逆转的先导化合物.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 期货 | |
50 mg | 询价 | 期货 |
产品描述 | HDAC3-IN-5 (9c) is a selective inhibitor of HDAC3, exhibiting IC50 values of 4.2 nM for HDAC3, 1629 nM for HDAC2, and 298.2 nM for HDAC1. In vitro, it effectively induces apoptosis in MV4-11 cells and reduces the expression of anti-apoptotic proteins. The development of selective HDAC3 inhibitors like HDAC3-IN-5 (9c) could serve as potential lead compounds for reversing Venetoclax resistance. |
靶点活性 | HDAC1:298.2 nM, HDAC3:4.2 nM, HDAC2:1629 nM |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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