Flumexadol

产品编号 T11302Cas号 30914-89-7

别名

Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analgesic.

Flumexadol

产品编号 T11302Cas号 30914-89-7

规格	价格	库存	数量
2 mg	¥ 643	5日内发货

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产品介绍

生物活性

产品描述	Flumexadol is a selective and affinity 5-HT2C receptor agonist with a Ki of 25 nM for the (+)-enantiomer of Flumexadol, and is 40-fold selective over the 5-HT2A receptor. Flumexadol is an orally active non-narcotic analgesic.
靶点活性	5-HT2C receptor:25 nM (ki)
体内活性	In rats and dogs dosed with 14C-Flumexadol (CERM1841), the 14C is excreted in the urine.?The 14C eliminated in the faeces of dog is significantly higher than for rat.?Conjugated metabolites, mostly glucuronides, accounted for the greater part of the urinary radioactivity in both species.?Biotransformation products are predominantly acids in both species, follows by significant amounts of basic metabolites, with very little neutral substances.?The major urinary metabolite in rats is 3-trifluoromethylbenzoic acid and 3-trifluoromethylhipuric acid.?In the dog it is 3-trifluoromethylmandelic acid in addition to the benzoic acid and its conjugate.?The basic products identified in the urine of both species are unchanged drug and 1-amino-2-hydroxy-2-(3-trifluoromethylphenyl)ethane, with the first predominating.

化学信息

分子量	231.21
分子式	C₁₁H₁₂F₃NO
CAS No.	30914-89-7

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 100 mg/mL (432.51 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.3251 mL	21.6254 mL	43.2507 mL	216.2536 mL
5 mM	0.8650 mL	4.3251 mL	8.6501 mL	43.2507 mL
10 mM	0.4325 mL	2.1625 mL	4.3251 mL	21.6254 mL
20 mM	0.2163 mL	1.0813 mL	2.1625 mL	10.8127 mL
50 mM	0.0865 mL	0.4325 mL	0.8650 mL	4.3251 mL
100 mM	0.0433 mL	0.2163 mL	0.4325 mL	2.1625 mL