Cariprazine hydrochloride (RGH188 hydrochloride) is an antipsychotic drug, is a D3 and D2 receptor partial agonist((Ki of 0.085 nM and 0.49 nM, respectively)

D2 receptor:0.49 nM (Ki) , 5-HT1A receptor:2.6 nM (Ki), D3 receptor:0.085 nM (Ki)

Cariprazine以剂量依赖和可饱和的方式占据D(2)/D(3)受体，最低剂量占据约5%的受体，而最高剂量显示出超过90%的占据率。与同等剂量的D(2)/D(3)占据相比，5-HT(1A)受体的占据率显著较低，其在raphe nuclei[1]的最大值约为30%。

Three monkeys using the following PET radioligands: [(11)C]MNPA (an agonist at D(2) and D(3) receptors), [(11)C]raclopride (an antagonist at D(2) and D(3) receptors), and [(11)C]WAY-100635 (an antagonist at 5-HT(1A) receptors). During each experimental day, the first PET measurement was a baseline study, the second after a low dose of cariprazine, and the third after the administration of a high dose[1].