TH588 hydrochloride

Name: TH588 hydrochloride
Brand: TargetMol
SKU: T60984
Rating: 4.5 (1 reviews)

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产品编号 T60984Cas号 1640282-30-9

TH588 hydrochlorid 是创新的 nudix 水解酶家族抑制剂，可选择性的高效结合并抑制MTH1 (NUDT1)，IC50值为 5 nM。

还可以

产品编号 T60984Cas号 1640282-30-9

TH588 hydrochlorid 是创新的 nudix 水解酶家族抑制剂，可选择性的高效结合并抑制MTH1 (NUDT1)，IC50值为 5 nM。

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生物活性

产品描述	TH588 hydrochloride is first-in-class inhibitor of nudix hydrolase family that selectively and effectively bind and inhibit the MTH1 with IC50 value of 5 nM.
体外活性	TH588 (2-10μM; 7-10 days) selectively and effectively kills U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC 50 s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM [1]. Cell Viability Assay [1] Cell Line: U2OS, HeLa, MDA-MB-231, MCF-7, SW480, SW620, VH10, HDFn cells Concentration: 2, 4, 6, 8, 10 μM Incubation Time: 7–10 days Result: Selectively and effectively killed U2OS, HeLa, MDA-MB-231, MCF-7, SW480, and SW620 cells with IC 50 s of 1.38, 0.83, 1.03, 1.08, 1.72, 0.8 μM, respectively, but was less toxic to several primary or immortalized cells.
体内活性	TH588 (30 mg/kg; s.c.; once daily for 35 days) reduces tumour growth in SW480 xenograft cancer model [1]. Animal Model: 5-6 weeks female SCID mice (SW480 xenograft cancer model) [1] Dosage: 30 mg/kg Administration: Subcutaneous injection (s.c.); once daily for 35 days Result: Reduced tumour growth in SW480 xenograft cancer model.