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KML-010是spiperone的衍生物。与spiperone相比,KML-010对5-HT(2A)受体的亲和力略低,但对5-HT(2C)和5-HT(1A)受体几乎不表现出亲和力,并且对多巴胺D2受体的亲和力显著降低。通过将spiperone的N(1)-苯基环改为KML-010中的甲基,其结合特性发生变化,从而可能提供更具选择性的药理学特征,以针对特定的受体。
KML-010是spiperone的衍生物。与spiperone相比,KML-010对5-HT(2A)受体的亲和力略低,但对5-HT(2C)和5-HT(1A)受体几乎不表现出亲和力,并且对多巴胺D2受体的亲和力显著降低。通过将spiperone的N(1)-苯基环改为KML-010中的甲基,其结合特性发生变化,从而可能提供更具选择性的药理学特征,以针对特定的受体。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | KML-010 is a derivative of spiperone. Compared to spiperone, KML-010 exhibits slightly reduced affinity for 5-HT(2A) receptors, almost no affinity for 5-HT(2C) and 5-HT(1A) receptors, and significantly decreased affinity for dopamine D2 receptors. The modification of the N(1)-phenyl ring in spiperone to a methyl group in KML-010 alters its binding characteristics, potentially offering more selective pharmacological properties for specific receptor targeting. |
别名 | KML010, KML 010 |
分子量 | 333.4 |
分子式 | C18H24FN3O2 |
CAS No. | 217635-62-6 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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