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L-K6L9 是由 L-亮氨酸和 L-赖氨酸的L-异构体组成的溶细胞肽。对LNCaP-CL1 雄激素独立型和22Rv1以及LNCaP雄激素依赖型人类前列腺癌细胞具有细胞毒性(LC50分别为4、4和6 µM),同时也对非癌性NIH3T3小鼠成纤维细胞和OL人类包皮成纤维细胞具有细胞毒性(LC50分别为7和5 µM)。在100 µM的浓度下,引起分离的人类红细胞溶血。
L-K6L9 是由 L-亮氨酸和 L-赖氨酸的L-异构体组成的溶细胞肽。对LNCaP-CL1 雄激素独立型和22Rv1以及LNCaP雄激素依赖型人类前列腺癌细胞具有细胞毒性(LC50分别为4、4和6 µM),同时也对非癌性NIH3T3小鼠成纤维细胞和OL人类包皮成纤维细胞具有细胞毒性(LC50分别为7和5 µM)。在100 µM的浓度下,引起分离的人类红细胞溶血。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 690 | 期货 | |
5 mg | ¥ 2,760 | 期货 | |
10 mg | ¥ 4,830 | 期货 | |
25 mg | ¥ 9,870 | 期货 |
产品描述 | L-K6L9, a cytolytic peptide comprised of L-isomer leucine and lysine, demonstrates cytotoxicity against both androgen-independent (LNCaP-CL1) and androgen-dependent (22Rv1 and LNCaP) human prostate cancer cells, with LC50 values of 4, 4, and 6 µM, respectively. It also affects non-cancerous cells, including NIH3T3 mouse fibroblasts and OL human foreskin fibroblasts, with LC50s of 7 and 5 µM, respectively. Furthermore, at a concentration of 100 µM, L-K6L9 induces hemolysis in isolated human erythrocytes. |
分子量 | 1804.48 |
分子式 | C90H174N22O15.XCF3COOH |
存储 | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | H2O: Soluble |
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