ADDA 5 hydrochloride

Name: ADDA 5 hydrochloride
Brand: TargetMol
SKU: T14126
Price: 745 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T14126Cas号 473268-46-1

ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO). For purified CcO from human glioma and bovine heart, the IC50s are 18.93 μM and 31.82 μM , respectively.

ADDA 5 hydrochloride

还可以

产品编号 T14126Cas号 473268-46-1

ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO). For purified CcO from human glioma and bovine heart, the IC50s are 18.93 μM and 31.82 μM , respectively.

规格	价格	库存	数量
2 mg	¥ 784	5日内发货

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产品介绍

生物活性

产品描述	ADDA 5 hydrochloride is a partial non-competitive inhibitor of cytochrome c oxidase (CcO). For purified CcO from human glioma and bovine heart, the IC50s are 18.93 μM and 31.82 μM , respectively.
靶点活性	CcO (human glioma):18.93 μM, CcO (bovine heart):31.82 μM
体外活性	ADDA 5 hydrochloride is a partial non-competitive inhibitor of CcO, with IC50s of 18.93 μM and 31.82 μM for purified CcO from human glioma and bovine heart, respectively. ADDA 5 inhibits CcO activity in UTMZ and Jx22-derived GSCs, with IC50s of 21.4 ± 3.9 μM and 15.5 ± 2.8 μM. ADDA 5 (25 μM) shows a growth inhibitory effect on UTMZ cells, with an EC50 of 8.17 μM[1].
体内活性	ADDA 5 does not causes detectable toxicity at up to 80 mg/kg in mice[1]. ADDA 5 (8 mg/kg, i.p.) obviously suppresses the growth of tumor in mice.

化学信息

分子量	406
分子式	C₂₄H₃₆ClNO₂
CAS No.	473268-46-1
密度	1.31g/cm3

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 65 mg/mL (160.10 mM), Sonication is recommended.

溶液配制表

	1mg	5mg	10mg	50mg
1 mM	2.4631 mL	12.3153 mL	24.6305 mL	123.1527 mL
5 mM	0.4926 mL	2.4631 mL	4.9261 mL	24.6305 mL
10 mM	0.2463 mL	1.2315 mL	2.4631 mL	12.3153 mL
20 mM	0.1232 mL	0.6158 mL	1.2315 mL	6.1576 mL
50 mM	0.0493 mL	0.2463 mL	0.4926 mL	2.4631 mL
100 mM	0.0246 mL	0.1232 mL	0.2463 mL	1.2315 mL