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RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM).
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
25 mg | ¥ 10,600 | 6-8周 | |
50 mg | ¥ 13,800 | 6-8周 | |
100 mg | ¥ 17,500 | 6-8周 |
产品描述 | RG-12915 is a selective antagonist of 5-HT3(IC50 value of 0.16 nM). |
靶点活性 | 5-HT3:0.16 nM |
体外活性 | RG 12915 is a displacer of binding of 5-hydroxytryptamine (5-HT3) binding sites with IC50 value of 0.16 nM, whereas failing to displace binding of ligands for the alpha-1, alpha-2 and beta adrenergic, 5-HT1 or 5-HT2 or cholinergic-muscarinic sites (IC50 values less than 1 μM). |
体内活性 | RG 12915 (1 mg/kg, p.o.) is highly protective against cisplatin-induced emesis in the dog. RG 12915 has no significant gastroprokinetic activity in the same species. RG 12915 has a lower ED50 value for attenuating cisplatin-induced emetic episodes in the ferret[1]. |
分子量 | 360.88 |
分子式 | C20H25ClN2O2 |
CAS No. | 136174-04-4 |
密度 | 1.31 g/cm3 (Predicted) |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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