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Gisadenafil (UK-369003) 是一种特异性磷酸二酯酶 5 (PDE5) 抑制剂,IC50 为 3.6 nM,可防止 cGMP 降解。
Gisadenafil (UK-369003) 是一种特异性磷酸二酯酶 5 (PDE5) 抑制剂,IC50 为 3.6 nM,可防止 cGMP 降解。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥ 1,300 | 现货 | |
5 mg | ¥ 2,920 | 现货 | |
10 mg | ¥ 4,320 | 现货 | |
25 mg | ¥ 6,880 | 现货 | |
50 mg | ¥ 9,330 | 现货 | |
100 mg | ¥ 12,500 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 3,520 | 现货 |
产品描述 | Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP. |
靶点活性 | PDE5A:3.6 nM, PDE1A:9.1 μM |
体外活性 | In COS-7 cells, the IC50 of Gisadenafil for PDE1A is 9.1 μM, an approximately 2500-fold difference in selectivity[2]. |
体内活性 | In male Tat-transgenic mice, Gisadenafil (2 mg/kg; i.p.) restores the dilation of small (<25 μm) arterioles following hypercapnia, although it fails to restore full dilation of larger (>25 μm) vessels. Gisadenafil largely restores the normal increase in cortical flow following hypercapnia in Tat-tg mice (17.5% above baseline)[2]. |
别名 | 吉沙那非, UK-369003 |
分子量 | 519.62 |
分子式 | C23H33N7O5S |
CAS No. | 334826-98-1 |
Smiles | C(C)C1=C2C(=NN1CCOC)C(=O)N=C(N2)C3=C(OCC)N=CC(S(=O)(=O)N4CCN(CC)CC4)=C3 |
密度 | 1.41 g/cm3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | DMSO: 55 mg/mL (105.85 mM) | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
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