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Bergapten (5-Methoxypsoralen) 是白芷中的一种香豆素,也是一种补骨脂素,可抑制细胞复制。
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Bergapten (5-Methoxypsoralen) 是白芷中的一种香豆素,也是一种补骨脂素,可抑制细胞复制。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
50 mg | ¥ 212 | 现货 | |
100 mg | ¥ 298 | 现货 | |
500 mg | ¥ 690 | 现货 | |
1 g | ¥ 927 | 现货 | |
5 g | ¥ 3,690 | 现货 | |
1 mL x 10 mM (in DMSO) | ¥ 250 | 现货 |
产品描述 | Bergapten (5-Methoxypsoralen), a psoralen, inhibits cell replication. |
体外活性 | 在对乙酰氨基酚(APAP)诱导的C57BL / 6J小鼠中,Bergapten能够发挥抗氧化活性,改善肝毒性. |
体内活性 | 在乳腺癌他莫昔芬敏感和耐药细胞中,Bergapten能够消除ERα,重新调整靶向ERα的膜信号,促进细胞有丝分裂的潜力。 |
细胞实验 | 5-Methoxypsoralen (5-MOP) is dissolved in DMSO and stored, and then diluted with appropriate medium (final DMSO <0.1%) before use[1]. The human colon adenocarcinoma cell line (COLO 205, from a 70-year-old male Caucasian) sre placed into 75-cm2 tissue culture flasks and grown in RPMI1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. The human stomach adenocarcinoma cell line are placed into 75-cm2 tissue culture flasks and grown in RPMI 1640 medium, supplemented with 10% fetal bovine serum, containing penicillin and streptomycin (100 Ig/mL) and 1 mM glutamine, at 37°C in a humidified atmosphere of 5% CO2 and 95% O2. SC-M1 and COLO 205 cells are treated with different concentrations of 5-MOP (0.05, 0.5, 5, 10, 25 and 50 mM) and incubated for 72 h for the dose-effect study of 5-MOP on NAT activity. To determine the time-course effect of 0.5 mM 5-MOP on NAT activity, the cells are incubated at 37AC and harvested at 12, 24, 48 and 72 h, respectively. 5-MOP is dissolved in DMSO and the final concentration of vehicle is <0.1%. Only DMSO (solvent) is added for the control regimen[1]. |
别名 | 香柑内酯, 佛手柑内酯, 5-Methoxypsoralen |
分子量 | 216.19 |
分子式 | C12H8O4 |
CAS No. | 484-20-8 |
Smiles | COC1=C2C=CC(=O)OC2=CC2=C1C=CO2 |
密度 | 1.368 g/cm3 |
存储 | keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
溶解度信息 | Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 20 mg/mL (92.51 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
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中药材名称 | 中药材拉丁名 | 性 | 味 | 归经 |
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白花前胡 | Peucedani Radix | 微寒 | 苦, 辛 | 肺 |
中成药名称 | 处方组成 | 中成药类型 |
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方剂名称 | 处方组成 | 剂型 | 处方来源 |
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