AZD-8529

Name: AZD-8529
Brand: TargetMol
SKU: T10432
Rating: 4.5 (1 reviews)

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产品编号 T10432Cas号 1092453-15-0

AZD-8529 is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.

AZD-8529

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产品编号 T10432Cas号 1092453-15-0

规格	价格	库存
2 mg	¥ 2,950	5日内发货
25 mg	¥ 11,800	1-2周
50 mg	¥ 15,400	1-2周
100 mg	¥ 23,900	1-2周

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产品描述	AZD-8529 is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 subtypes.
靶点活性	mGluR2:（EC50）285 nM
体外活性	AZD-8529 potentiates the effects of glutamate at mGluR2 (EC50: 195 nM). It does not elicit antagonist responses on mGluRs at 25 μM.
体内活性	AZD-8529 (30 mg/kg; i.p.) decreases the increased extracellular dopamine induced by nicotine in accumbens shell of freely-moving rats. AZD-8529 (0.3-mg/kg, i.m.) reduces nicotine priming-induced and cue-induced reinstatement in squirrel monkeys.