AGN 194310

Name: AGN 194310
Brand: TargetMol
SKU: T14143
Price: 333 USD
Availability: InStock
Rating: 4.5 (1 reviews)

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产品编号 T14143Cas号 229961-45-9

别名 VTP-194310

AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].

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AGN 194310

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产品编号 T14143 别名 VTP-194310Cas号 229961-45-9

AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].

规格	价格	库存
5 mg	¥ 4,570	8-10周
25 mg	¥ 14,300	8-10周
50 mg	¥ 18,700	8-10周
100 mg	¥ 25,500	8-10周
1 mL x 10 mM (in DMSO)	¥ 4,930	8-10周

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产品介绍

生物活性

产品描述	AGN 194310 (VTP-194310) is retinioic acid receptors (RARs) pan-antagonist. The Kd values of 3 nM, 2 nM, 5 nM for RARα, RARβ, RARγ, respectively[1][2].
靶点活性	RARα:3 nM （kd）, RARβ:2 nM （kd）, RARγ:5 nM （kd）
体外活性	AGN194310 potently inhibits colony formation by all three lines, with IC50 values of 16 nM for LNCaP cells; 18 nM for PC3 cells; and 34 nM for DU-145 cells[2]. AGN 194310 (50 nM, 100 nM; LNCaP, PC-3 and DU-145 cells) inhibits colony formation at concentrations of 50 nM and 100 nM alone and in combination with TTNPB[2]. AGN 194310 (1 μM; 72 hours; LNCaP cells) treatment results in 80% apoptosis[2].
体内活性	AGN 194310 (0.5 mg/kg/day; oral gavage; every day; for 10 days; female C57Bl/6J mice) treatment increases the number of granulocytes across haemopoietic compartments. A significant increase in the frequency of granulocyte-progenitor cells is observed in the bone marrow of mice after treatment with AGN194310[3].
别名	VTP-194310

化学信息

分子量	424.55
分子式	C₂₈H₂₄O₂S
CAS No.	229961-45-9
密度	1.26 g/cm3 (Predicted)

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 50 mg/mL (117.77 mM), Sonication is recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3554 mL	11.7772 mL	23.5544 mL	117.7718 mL
5 mM	0.4711 mL	2.3554 mL	4.7109 mL	23.5544 mL
10 mM	0.2355 mL	1.1777 mL	2.3554 mL	11.7772 mL
20 mM	0.1178 mL	0.5889 mL	1.1777 mL	5.8886 mL
50 mM	0.0471 mL	0.2355 mL	0.4711 mL	2.3554 mL
100 mM	0.0236 mL	0.1178 mL	0.2355 mL	1.1777 mL