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TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
5 mg | ¥ 931 | 期货 | |
10 mg | ¥ 1,493 | 期货 | |
50 mg | ¥ 4,385 | 期货 | |
100 mg | ¥ 7,598 | 期货 |
产品描述 | TAS-103 is a dual inhibitor of DNA topoisomerase I/II, used for cancer research. |
体外活性 | TAS-103 is a dual inhibitor of DNA topoisomerase I/II. TAS-103 (0.1-10 μM) is active on CCRF-CEM cells, with an IC50 value of 5 nM. TAS-103 (0.1 μM) significantly increases levels of topo IIα FITC immunofluorescence in individual CCRF-CEM cells[1]. TAS-103 (0.01-1 μM) is highly cytotoxic to Lewis lung carcinoma (LLC) cells, and Liposomal TAS-103 is almost as active as free TAS-103[2]. TAS-103 inhibits the viability of HeLa cells, with an IC50 of 40 nM. TAS-103 (10 μM) disrupts signal recognition particle (SRP) complex formation, and induces destabilization of SRP14 and SRP19 and its eventual degradation[3]. |
体内活性 | TAS-103 (30 mg/kg, i.v.) causes significant tumor growth suppression in mice bearing Lewis lung carcinoma (LLC) cells, without obvious body weight loss, and the liposomal TAS-103 is more active than free TAS-103[2]. |
细胞实验 | CCRF-CEM human acute lymphoblastic leukaemia cells are grown in RPMI-1640 supplemented with 3 mM l-glutamine, 10% foetal bovine serum, 50 U/mL of penicillin, and 40 μg/mL of streptomycin at 37°C in a humidified atmosphere containing 5% CO2. TAS-103, CPT and DACA are dissolved in DMSO. Exponentially growing cells (~5 × 105) are exposed to either of the drugs for 2 hrs. Following drug exposure, cells are washed twice by centrifugation (400 × g, 3 min) in cold phosphate-buffered saline[1]. |
分子量 | 333.38 |
分子式 | C20H19N3O2 |
CAS No. | 174634-08-3 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度信息 | DMSO: Soluble |
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