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ELOVL6-IN-5(compound B)是针对ELOVL6的抑制剂,后者为长链脂肪酸家族6的延长酶,负责饱和及单不饱和长链脂肪酸的延长,并且是糖尿病治疗中的有效靶点。此化合物能在饮食诱导肥胖(DIO)的小鼠模型中有效降低肝脏脂肪酸水平,尽管如此,通过ELOVL6-IN-5引起的ELOVL6抑制并未改善胰岛素抵抗问题。
ELOVL6-IN-5(compound B)是针对ELOVL6的抑制剂,后者为长链脂肪酸家族6的延长酶,负责饱和及单不饱和长链脂肪酸的延长,并且是糖尿病治疗中的有效靶点。此化合物能在饮食诱导肥胖(DIO)的小鼠模型中有效降低肝脏脂肪酸水平,尽管如此,通过ELOVL6-IN-5引起的ELOVL6抑制并未改善胰岛素抵抗问题。
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
10 mg | 询价 | 10-14周 | |
50 mg | 询价 | 10-14周 |
产品描述 | ELOVL6-IN-5 (compound B) acts as an inhibitor targeting the elongase enzyme of the long-chain fatty acid family 6 (ELOVL6). This enzyme is pivotal in the elongation process of saturated and monounsaturated long-chain fatty acids, marking it as a strategic target for diabetes intervention. In a mouse model of diet-induced obesity (DIO), ELOVL6-IN-5 effectively reduces hepatic fatty acid levels. However, it fails to enhance insulin sensitivity . |
分子量 | 439.45 |
分子式 | C20H20F3N3O3S |
CAS No. | 1135000-36-0 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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