购物车
- 全部删除
您的购物车当前为空
GSK2945 hydrochloride (1438071-12-5 free base)
还可以产品编号 T11490L
别名 GSK2945 hydrochloride
GSK2945 hydrochloride is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.
GSK2945 hydrochloride (1438071-12-5 free base)
还可以产品编号 T11490L 别名 GSK2945 hydrochloride
GSK2945 hydrochloride is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism.
| 规格 | 价格 | 库存 | 数量 |
|---|---|---|---|
| 5 mg | ¥ 3,010 | 期货 | |
| 10 mg | ¥ 4,710 | 期货 | |
| 50 mg | ¥ 14,060 | 期货 | |
| 100 mg | ¥ 19,160 | 期货 |
大包装 & 定制
加入购物车
实验操作小课堂
查看更多 联系我们获取更多批次信息
资源下载
产品介绍
生物活性
化学信息
| 产品描述 | GSK2945 hydrochloride is a highly specific Rev-erbα/REV-ERBα (mouse/human reverse erythroblastosis virus α) antagonist (EC50s: 21.5 μM and 20.8 μM). It enhances cholesterol 7α-hydroxylase (CYP7A1) level and cholesterol metabolism. |
| 体外活性 | GSK2945 (20 μM) treatment also increases Lrh-1/LRH-1 (a known hepatic activator of Cyp7a1/CYP7A1) mRNA and protein.GSK2945 dose-dependently enhances the transcriptional activity of Rev-erbα and a Bmal1 (a target gene of REV-ERBs) luciferase reporter (EC50 of 2.05 μM). GSK2945 (20 μM; 12 hours and 24 hours; mouse and human primary hepatocytes) treatment increases levels of Cyp7a1/CYP7A1 in mouse and human primary hepatocytes. |
| 体内活性 | GSK2945 treatment increases hepatic mouse cholesterol 7α-hydroxylase (Cyp7a1) level and lowers plasma cholesterol in wild-type mice. |
| 别名 | GSK2945 hydrochloride |
| 分子量 | 457.8 |
| 分子式 | C20H19Cl3N2O2S |
| 密度 | no data available |
储存&溶解度
| 存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
计算器
体内实验配液计算器
请在以下方框中输入您的动物实验信息后点击计算，可以得到母液配置方法和体内配方的制备方法：
比如您的给药剂量是 10 mg/kg ，每只动物体重 20 g ，给药体积 100 μL ， 
剂量转换
对于不同动物的给药剂量换算，您也可以参考 更多
关键词
评论列表
预览
Related Tags: buy GSK2945 hydrochloride (1438071-12-5 free base) | purchase GSK2945 hydrochloride (1438071-12-5 free base) | GSK2945 hydrochloride (1438071-12-5 free base) cost | order GSK2945 hydrochloride (1438071-12-5 free base) | GSK2945 hydrochloride (1438071-12-5 free base) chemical structure | GSK2945 hydrochloride (1438071-12-5 free base) in vivo | GSK2945 hydrochloride (1438071-12-5 free base) in vitro | GSK2945 hydrochloride (1438071-12-5 free base) formula | GSK2945 hydrochloride (1438071-12-5 free base) molecular weight
嗨！很高兴为您提供帮助！
评论内容