Tirbanibulin dihydrochloride

产品编号 T15674Cas号 1038395-65-1

别名 KX-01 (dihydrochloride)|||KX2-391 (dihydrochloride)

Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).

产品编号 T15674别名 KX-01 (dihydrochloride), KX2-391 (dihydrochloride)Cas号 1038395-65-1

Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).

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生物活性

产品描述	Tirbanibulin is an inhibitor of Src that targets the peptide substrate site of Src (GI50: 9-60 nM in cancer cell lines).
靶点活性	Src (HepG2):60 nM, Src (PLC/PRF/5):13 nM, Src (HuH-7):(GI50)9 nM, Src (Hep3B):26 nM
体外活性	Tirbanibulin (KX2-391) is found to inhibit certain leukemia cells that are resistant to current commercially available drugs, such as those derived from chronic leukemia cells with the T3151 mutation. KX2-391 displays steep dose-response curves against Huh7 (GI50=9 nM), PLC/PRF/5 (GI50=13 nM), Hep3B (GI50=26 nM), and HepG2 (GI50=60 nM), four hepatic cell cancer (HCC) cell lines[1]. Tirbanibulin is evaluated in engineered Src driven cell growth assays inNIH3T3/c-Src527F and SYF/c-Src527F cells and exhibits GI50 with 23 nM and 39 nM, respectively[2].
体内活性	In pre-clinical animal models of cancer, Tirbanibulin (p.o.) is shown to inhibit primary tumor growth and to suppress metastasis[2].
别名	KX-01 (dihydrochloride), KX2-391 (dihydrochloride)

化学信息

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 33.33 mg/mL (66.07 mM), Sonication is recommended.

溶液配制表

DMSO