SB-399885 hydrochloride

产品编号 T12843Cas号 402713-81-9

别名

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

SB-399885 hydrochloride

产品编号 T12843Cas号 402713-81-9

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

规格	价格	库存
2 mg	¥ 489	5日内发货
25 mg	¥ 4,310	6-8周
50 mg	¥ 5,610	6-8周
100 mg	¥ 10,300	6-8周

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产品介绍

生物活性

产品描述

SB-399885 hydrochloride is an antagonist of 5-HT6 receptor.

体内活性

SB-399885 hydrochloride 10 mg/kg significantly increases wakefulness (W) (F(3,15)=3.32, P<0.05) while slow wave sleep (SWS), rapid-eye-movement sleep (REMS) and the number of REM periods are reduced (F(3,15)=4.0, P<0.01; F(3,15)=3.14, P<0.05 and F(3,15)=2.62, P<0.05, respectively) Compare with the control vehicle . Analysis of sleep variables in 2-h blocks shows that SB-399885 hydrochloride 10 mg/kg increases W (F(3,15)=5.48, P<0.01) and reduces SWS (F(3,15)=5.42, P<0.01) and REMS (F(3,15)= 4.05, P<0.01) during the first 2-h period. SB-399885 hydrochloride 5 and 10 mg/kg augment light sleep over the first (F(3,15)=3.46,P<0.01 and F(3,15)= 3.65, P<0.01, respectively) and the second (F(3,15)=3.23, P<0.05 and F(3,15)=3.08, P<0.05, respectively) 2-h recording periods. SB-399885 hydrochloride 10 mg/kg significantly increases REMS latency (F(3,15)=3.60, P<0.01) and reduces the number of REM periods during the first 2-h of recording (F(3,15)=3.88, P<0.01).

化学信息

分子量	482.81
分子式	C₁₈H₂₂Cl₃N₃O₄S
CAS No.	402713-81-9

储存&溶解度

存储

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

溶解度信息

DMSO: 125 mg/mL (258.90 mM), Sonication and heating are recommended.

溶液配制表

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0712 mL	10.3560 mL	20.7121 mL	103.5604 mL
5 mM	0.4142 mL	2.0712 mL	4.1424 mL	20.7121 mL
10 mM	0.2071 mL	1.0356 mL	2.0712 mL	10.3560 mL
20 mM	0.1036 mL	0.5178 mL	1.0356 mL	5.1780 mL
50 mM	0.0414 mL	0.2071 mL	0.4142 mL	2.0712 mL
100 mM	0.0207 mL	0.1036 mL	0.2071 mL	1.0356 mL